Journal ArticleDOI
Activation of rat brain protein kinase C by lipid oxidation products.
TLDR
Since oxidation of unsaturated fatty acids to hydroperoxides is the first event in lipid peroxidation, activation of PKC by hydroperoxy fatty acids may be an early cellular response to oxidative stress.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1988-09-30. It has received 83 citations till now. The article focuses on the topics: Unsaturated fatty acid & Fatty acid.read more
Citations
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Journal ArticleDOI
Redox Regulation of Cellular Signalling
Hideaki Kamata,Hajime Hirata +1 more
TL;DR: Evidence shows that the cell's fate is determined by cross talk between the cellular signalling pathways and the cellular redox state through a complicated regulation mechanism.
Journal ArticleDOI
Protein kinase C signaling and oxidative stress.
Rayudu Gopalakrishna,Susan Jaken +1 more
TL;DR: KPCs contain unique structural features that are susceptible to oxidative modification, and are a logical candidate for redox modification by oxidants and antioxidants that may in part determine their cancer-promoting and anticancer activities, respectively.
Journal ArticleDOI
Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.
Farhad Parhami,Zhuang T. Fang,Alan M. Fogelman,Ali Andalibi,Mary C. Territo,Judith A. Berliner +5 more
TL;DR: Evidence is presented that induction of neutrophil binding by LPS is actually suppressed by agents that elevated cAMP levels, and a role for this transcription factor in activation of monocyte-endothelial interactions is suggested.
Journal ArticleDOI
Arsenite induces apoptosis in chinese hamster ovary cells by generation of reactive oxygen species
TL;DR: Results lead to a working hypothesis that arsenite‐induced apoptosis in CHO‐K1 cells is triggered by the generation of hydrogen peroxide, followed by a copper‐mediated Fenton reaction that catalyzes the production of hydroxyl radicals, which selectively activates protein kinase through de novo synthesis of macromolecules.
Journal ArticleDOI
Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids.
TL;DR: An increase in glucose concentration in the medium from 5 to 30 mM transiently enhanced diacylglycerol mass and activated protein kinase C in glomeruli isolated from nondiabetic rats as assessed by translocation of enzyme activity from the soluble to participate fraction.
References
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Journal ArticleDOI
Studies and perspectives of protein kinase C
TL;DR: A novel role of this protein kinase system seems to give a logical basis for clarifying the biochemical mechanism of signal transduction, and to add a new dimension essential to the understanding of cell-to-cell communication.
Journal ArticleDOI
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
TL;DR: Kinetic analysis indicates that TPA can substitute for diacylglycerol and greatly increases the affinity of the enzyme for Ca2+ as well as for phospholipid, and various phorbol derivatives which have been shown to be active in tumor promotion are also capable of activating this protein kinase in in vitro systems.
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Prooxidant states and tumor promotion.
TL;DR: Prooxidant states can be caused by different classes of agents, including hyperbaric oxygen, radiation, xenobiotic metabolites and Fenton-type reagents, modulators of the cytochrome P-450 electron-transport chain, peroxisome proliferators, inhibitors of the antioxidant defense, and membrane-active agents.
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A potential second messenger role for unsaturated fatty acids: activation of Ca2+-dependent protein kinase.
TL;DR: The release of arachidonate, which is triggered in many cell types by ligand-receptor interactions, could play a second messenger role in the regulation of cellular function by activation of protein kinase C.
Journal ArticleDOI
Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes.
TL;DR: It is concluded that considerable amounts of biologically reactive carbonyl derivatives are released in lipid peroxidation and yet may not be picked up by the thiobarbituric acid reaction.