Journal ArticleDOI
Acute and Longer- Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report
A. John Rush,Madhukar H. Trivedi,Stephen R. Wisniewski,Andrew A. Nierenberg,Jonathan W. Stewart,Diane Warden,George Niederehe,Michael E. Thase,Philip W. Lavori,Barry D. Lebowitz,Patrick J. McGrath,Jerrold F. Rosenbaum,Harold A. Sackeim,David J. Kupfer,James F. Luther,Maurizio Fava +15 more
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TLDR
The acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial are described and compared.Abstract:
Objective: This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. Method: A broadly representative adult outpatient sample with nonpsychotic major depressive disorder received one (N=3,671) to four (N=123) successive acute treatment steps. Those not achieving remission with or unable to tolerate a treatment step were encouraged to move to the next step. Those with an acceptable benefit, preferably symptom remission, from any particular step could enter a 12-month naturalistic follow-up phase. A score of ≤5 on the Quick Inventory of Depressive Symptomatology–Self-Report (QIDS-SR 16 ) (equivalent to ≤7 on the 17-item Hamilton Rating Scale for Depression [HRSD 17 ]) defined remission; a QIDS-SR 16 total score of ≥11 (HRSD 17 ≥14) defined relapse. Results: The QIDS-SR 16 remission rates were 36.8%, 30.6%, 13.7%, and 13.0% for the first, second, t...read more
Citations
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Journal ArticleDOI
Metabolomic biosignature differentiates melancholic depressive patients from healthy controls
Yashu Liu,Lynn Yieh,Tao Yang,Wilhelmus Drinkenburg,Pieter J. Peeters,Thomas Steckler,Vaibhav A. Narayan,Gayle M. Wittenberg,Jieping Ye +8 more
TL;DR: An ensemble feature selection framework (EFSF) in which features are first clustered, and learning then takes place on the cluster centroids, retaining information about correlated features during the feature selection process rather than discarding them as most machine learning methods will do.
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Potential Use of MicroRNA for Monitoring Therapeutic Response to Antidepressants
TL;DR: A detailed overview of biomarkers is given, particularly the major studies that have investigated microRNA in relationship to antidepressant treatment response and microRNA as biomarkers of antidepressant response.
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Predicting outcome of depression using the depressive symptom profile: the Leiden Routine Outcome Monitoring Study.
Martijn S. van Noorden,Esther M. van Fenema,Nic J.A. van der Wee,Frans G. Zitman,Erik J. Giltay +4 more
TL;DR: The predictive value of items for individual depressive symptoms measured with the self‐rated Beck Depression Inventory‐Revised (BDI‐II) self‐report scale on outcome in a large naturalistic cohort of depressive outpatients is investigated.
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Trigeminal nerve stimulation (TNS) protocol for treating major depression: An open-label proof-of-concept trial
TL;DR: Data analysis underscores a significant participation of TNS in ameliorating depressive symptoms of patients with moderate or severe depressive episode, and the results, however significant, need to be taken as hypothesis-driven given the study design.
Journal ArticleDOI
The Cost-Effectiveness of Cognitive Behavioral Therapy Versus Second-Generation Antidepressants for Initial Treatment of Major Depressive Disorder in the United States: A Decision Analytic Model.
TL;DR: This analysis aims to estimate the 1- and 5-year cost-effectiveness of CBT versus SGA, along with overall uncertainty in the health economic consequences of each treatment, and to determine what additional evidence could reduce this uncertainty, thus better informing guidelines and policy surrounding depression treatment.
References
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Journal ArticleDOI
Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
Madhukar H. Trivedi,A. John Rush,Stephen R. Wisniewski,Andrew A. Nierenberg,Diane Warden,Louise Ritz,Grayson Norquist,Robert H Howland,Barry D. Lebowitz,Patrick J. McGrath,Kathy Shores-Wilson,Melanie M. Biggs,Goundappa K. Balasubramani,Maurizio Fava +13 more
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Journal ArticleDOI
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Journal ArticleDOI
Cross-Validation of Item Selection and Scoring for the SF-12 Health Survey in Nine Countries: Results from the IQOLA Project
Barbara Gandek,John E. Ware,Neil K. Aaronson,Giovanni Apolone,Jakob B. Bjorner,John Brazier,Monika Bullinger,Stein Kaasa,Alain Leplège,Luis Prieto,Marianne Sullivan +10 more
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