Journal ArticleDOI
Acute and Longer- Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report
A. John Rush,Madhukar H. Trivedi,Stephen R. Wisniewski,Andrew A. Nierenberg,Jonathan W. Stewart,Diane Warden,George Niederehe,Michael E. Thase,Philip W. Lavori,Barry D. Lebowitz,Patrick J. McGrath,Jerrold F. Rosenbaum,Harold A. Sackeim,David J. Kupfer,James F. Luther,Maurizio Fava +15 more
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TLDR
The acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial are described and compared.Abstract:
Objective: This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. Method: A broadly representative adult outpatient sample with nonpsychotic major depressive disorder received one (N=3,671) to four (N=123) successive acute treatment steps. Those not achieving remission with or unable to tolerate a treatment step were encouraged to move to the next step. Those with an acceptable benefit, preferably symptom remission, from any particular step could enter a 12-month naturalistic follow-up phase. A score of ≤5 on the Quick Inventory of Depressive Symptomatology–Self-Report (QIDS-SR 16 ) (equivalent to ≤7 on the 17-item Hamilton Rating Scale for Depression [HRSD 17 ]) defined remission; a QIDS-SR 16 total score of ≥11 (HRSD 17 ≥14) defined relapse. Results: The QIDS-SR 16 remission rates were 36.8%, 30.6%, 13.7%, and 13.0% for the first, second, t...read more
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Journal ArticleDOI
Brain structural effects of treatments for depression and biomarkers of response: a systematic review of neuroimaging studies.
TL;DR: The findings show consistently that higher pre-treatment ACC volume is associated with response to AD, ECT and CBT, and underline the potential of brain biomarkers for the implementation in clinical practice as an additive feature within the process of treatment selection.
Journal ArticleDOI
Predictors of 12-week remission in a nationwide cohort of people with depressive disorders: the CRESCEND study.
Jae-Min Kim,Sung-Wan Kim,Robert Stewart,Seon-Young Kim,Jin-Sang Yoon,Sung-Won Jung,Min Soo Lee,Hyeon Woo Yim,Tae Youn Jun +8 more
TL;DR: To estimate the 12‐week remission rate of patients with depressive disorders and predictors of this in a naturalistic clinical setting in South Korea, a large number of patients have shown remission in the past 12 weeks.
Journal ArticleDOI
Pharmacogenetics in Psychiatry: An Update on Clinical Usability.
Ron H.N. van Schaik,Daniel J. Müller,Daniel J. Müller,Alessandro Serretti,Magnus Ingelman-Sundberg +4 more
TL;DR: An update is provided regarding genotyping (SNP analysis/arrays/NGS), structural variant detection (star-alleles/CNVs/hybrid alleles), genotype-to-phenotype translations, cost-effectiveness, and actionability of results (FDA/CPIC/PharmGKB) regarding clinical importance of pre-emptive pharmacogenomic testing for prescription of antidepressants and antipsychotics.
Journal ArticleDOI
Pharmacogenetic considerations in the treatment of psychiatric disorders.
Falk W. Lohoff,Thomas N. Ferraro +1 more
TL;DR: Although current data are too sparse to allow the development of guidelines for using pharmacogenetic testing in routine clinical practice, the field of psychiatric pharmacogenetics is rapidly developing and identification of genetic biomarkers that predict therapeutic response and risk of side effects will ultimately help the practitioner to choose effective and safe treatment for patients suffering from psychiatric disorders.
Journal ArticleDOI
Does early response predict outcome in psychotherapy and combined therapy for major depression
TL;DR: Although a number of early nonresponsive patients will achieve remission, this study points out that these patients are at risk factor for ultimate treatment failure, and could be an indication for clinicians to adapt their treatment strategy.
References
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Journal ArticleDOI
Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
Madhukar H. Trivedi,A. John Rush,Stephen R. Wisniewski,Andrew A. Nierenberg,Diane Warden,Louise Ritz,Grayson Norquist,Robert H Howland,Barry D. Lebowitz,Patrick J. McGrath,Kathy Shores-Wilson,Melanie M. Biggs,Goundappa K. Balasubramani,Maurizio Fava +13 more
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Journal ArticleDOI
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Journal ArticleDOI
Cross-Validation of Item Selection and Scoring for the SF-12 Health Survey in Nine Countries: Results from the IQOLA Project
Barbara Gandek,John E. Ware,Neil K. Aaronson,Giovanni Apolone,Jakob B. Bjorner,John Brazier,Monika Bullinger,Stein Kaasa,Alain Leplège,Luis Prieto,Marianne Sullivan +10 more
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Journal ArticleDOI
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