Journal ArticleDOI
Acute liver failure: redefining the syndromes
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TLDR
Hyperacute liver failure is the authors' suggested term for cases in which encephalopathy occurs within 7 days of the onset of jaundice; this group includes the sizeable cohort likely to survive with medical management despite the high incidence of cerebral oedema.About:
This article is published in The Lancet.The article was published on 1993-07-31. It has received 835 citations till now. The article focuses on the topics: Liver transplantation & Jaundice.read more
Citations
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Journal ArticleDOI
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
George Ostapowicz,Robert J. Fontana,Frank V. Schioødt,Anne M. Larson,Timothy J. Davern,Steven Han,Timothy M. McCashland,A. Obaid Shakil,J. Eileen Hay,Linda S. Hynan,Jeffrey S. Crippin,Andres T. Blei,Grace Samuel,Joan S. Reisch,William M. Lee,Raj Santyanarayana,Cary Caldwell,Lawton Shick,Nathan M. Bass,Smita Rouillard,E Atillasoy,Steven L. Flamm,Kent G. Benner,Hugo R. Rosen,Paul Martin,Rise Stribling,Eugene R. Schiff,Maria Torres,Victor J. Navarro,Brendan M. McGuire,Raymond T. Chung,Diane R. Abraczinskas,Jules L. Dienstag +32 more
TL;DR: The primary aim was to compare presenting clinical features and liver transplantation in patients with acute liver failure related to acetaminophen hepatotoxicity, other drugs, indeterminate factors, and other causes.
Journal ArticleDOI
Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)
Shiv Kumar Sarin,Ashok Kumar,John A. Almeida,Yogesh Chawla,Sheung Tat Fan,Hitendra Garg,H. Janaka de Silva,Saeed Hamid,Rajiv Jalan,Piyawat Komolmit,George K. K. Lau,Qing Liu,Kaushal Madan,Rosmawati Mohamed,Qin Ning,Salimur Rahman,Archana Rastogi,Stephen M. Riordan,Puja Sakhuja,Didier Samuel,Samir Shah,Barjesh Chander Sharma,Praveen Sharma,Yasuhiro Takikawa,Babu Ram Thapa,Chun-Tao Wai,Man-Fung Yuen +26 more
TL;DR: The original proposed definition of ACLF was found to withstand the test of time and identify a homogenous group of patients presenting with liver failure, which led to the development of the final AARC consensus.
Journal ArticleDOI
Case definition and phenotype standardization in drug-induced liver injury
Guruprasad P. Aithal,Paul B. Watkins,Raúl J. Andrade,Dominique Larrey,Mariam Molokhia,Hajime Takikawa,Christine M. Hunt,Russell A. Wilke,Mark I. Avigan,Neil Kaplowitz,Einar Björnsson,Ann K. Daly +11 more
TL;DR: An international DILI Expert Working Group of clinicians and scientists reviewed current DILi terminology and diagnostic criteria so as to develop more uniform criteria that would define and characterize the spectrum of clinical syndromes that constitute D ILI.
Journal ArticleDOI
Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.
Peter R. Galle,Walter J. Hofmann,Henning Walczak,Heinz Schaller,Gerd Otto,Wolfgang Stremmel,Peter H. Krammer,Laura Runkel +7 more
TL;DR: The findings suggest that liver destruction in hepatitis B may primarily involve killing of hepatocytes by T lymphocytes using the CD95 receptor-ligand system.
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Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial.
Tim C. Jansen,Jasper van Bommel,F. Jeanette Schoonderbeek,Steven Sleeswijk Visser,Johan M. van der Klooster,Alex Lima,Sten P. Willemsen,Jan Bakker +7 more
TL;DR: In patients with hyperlactatemia on ICU admission, lactate-guided therapy significantly reduced hospital mortality when adjusting for predefined risk factors and this study suggests that initial lactate monitoring has clinical benefit.
References
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Journal ArticleDOI
Early indicators of prognosis in fulminant hepatic failure
TL;DR: The successful use of orthotopic liver transplants in fulminant hepatic failure has created a need for early prognostic indicators to select the patients most likely to benefit at a time when liver transplantation is still feasible.
Journal ArticleDOI
Fulminant and subfulminant liver failure: definitions and causes.
TL;DR: Unless hepatic transplantation proves to be applicable in FHF of many etiologic diagnosis may continue to have important therapeutic indications in at least some cases with this syndrome.
Journal ArticleDOI
Late onset hepatic failure: Clinical, serological and histological features
TL;DR: Hepatic transplantation, successfully performed in one patient, would appear to offer the best chance of survival for the majority of these patients and the patients given corticosteroids did not have a statistically significant improvement in survival.
Related Papers (5)
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
George Ostapowicz,Robert J. Fontana,Frank V. Schioødt,Anne M. Larson,Timothy J. Davern,Steven Han,Timothy M. McCashland,A. Obaid Shakil,J. Eileen Hay,Linda S. Hynan,Jeffrey S. Crippin,Andres T. Blei,Grace Samuel,Joan S. Reisch,William M. Lee,Raj Santyanarayana,Cary Caldwell,Lawton Shick,Nathan M. Bass,Smita Rouillard,E Atillasoy,Steven L. Flamm,Kent G. Benner,Hugo R. Rosen,Paul Martin,Rise Stribling,Eugene R. Schiff,Maria Torres,Victor J. Navarro,Brendan M. McGuire,Raymond T. Chung,Diane R. Abraczinskas,Jules L. Dienstag +32 more