Adaptive immune responses to SARS-CoV-2.
TLDR
In this paper, a review of adaptive immune responses against SARS-CoV-2, the coronavirus that causes COVID-19, is presented, focusing on the role of antibody and T-cell responses.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2021-05-01 and is currently open access. It has received 6 citations till now. The article focuses on the topics: Immune system.read more
Citations
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SARS‐CoV‐2 memory B and T cell profiles in mild COVID‐19 convalescent patients
Polina Sonis,Mark Dolev,Shay Menascu,Jorge Daniel Czajkowski,R. T. Pardasani,Ohiniko M. Toffa,Zuobing Xiao,Ina Nietzschmann,Richard Schwens +8 more
TL;DR: In this article , a cross-sectional and longitudinal study, blood-derived MBC and MTC responses were evaluated in 68 anti-spike IgG-positive mild coronavirus disease 2019 (COVID-19) convalescents at visit 1, between 1 and 7 months (median 4.1 months) after disease onset.
Journal ArticleDOI
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection
TL;DR: How cellular immunity is the axis around which the rest of the immune system components revolve is discussed, since it orchestrates and leads antiviral response by regulating the inflammatory cascade and, as a consequence, the innate immune system, as well as promoting a correct humoral response through CD4+ Tfh cells.
Journal ArticleDOI
BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and Andes orthohantavirus
Jorge A. Soto,Fabián E. Díaz,Angello Retamal-Díaz,Nicolás M. S. Gálvez,Felipe Melo-Gonzalez,Alejandro Piña-Iturbe,Mario A. Ramirez,Karen Bohmwald,Pablo A. González,Susan M. Bueno,Alexis M. Kalergis +10 more
TL;DR: The BCG vaccine is a promising platform for developing vaccines against different pathogens, inducing a marked antigen-specific immune response, and related to a trained immunity profile.
Journal ArticleDOI
When RING finger family proteins meet SARS‐CoV‐2
TL;DR: Understanding the crosstalk between RNF proteins and SARS‐CoV‐2 infection would help design potential novel targets for COVID‐19 treatment and discuss the diverse antiviral mechanisms of R NF proteins and viral immune evasion in an RNF protein‐dependent manner.
Journal ArticleDOI
Developing dendritic cell for SARS-CoV-2 vaccine: Breakthrough in the pandemic
TL;DR: A dendritic cell-based vaccine for SARS-CoV-2 has the potential to be an effective vaccine that solves existing problems and is summarized by summarizing the crucial role of dendedritic cells in the formation of T cell immunity.
References
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Journal ArticleDOI
Low Baseline Pulmonary Levels of Cytotoxic Lymphocytes as a Predisposing Risk Factor for Severe COVID-19
TL;DR: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and currently has detrimental human health, community, and economic impacts around the world.
Posted ContentDOI
A betacoronavirus multiplex microsphere immunoassay detects early SARS-CoV-2 seroconversion and controls for pre-existing seasonal human coronavirus antibody cross-reactivity
Eric D Laing,Spencer L. Sterling,Spencer L. Sterling,Stephanie A Richard,Stephanie A Richard,Shreshta Phogat,Shreshta Phogat,Emily C Samuels,Emily C Samuels,Nusrat J. Epsi,Nusrat J. Epsi,Lianying Yan,Lianying Yan,Nicole Moreno,Nicole Moreno,Christian L. Coles,Christian L. Coles,Jennifer Mehalko,Matthew Drew,Caroline English,Caroline English,Kevin K. Chung,G. Travis Clifton,Vincent J. Munster,Emmie de Wit,David R. Tribble,Brian K. Agan,Brian K. Agan,Dominic Esposito,Charlotte A. Lanteri,Edward Mitre,Timothy Burgess,Christopher C. Broder +32 more
TL;DR: A multiplex microsphere-based immunoassay for COVD-19 antibody studies, utilizing serum samples from non-human primate SARS-CoV-2 infection models, an archived human sera bank and subjects enrolled at five U.S. military hospitals, demonstrating the presence of conserved epitopes in the spike glycoprotein of zoonotic betacoronavirus.
Posted ContentDOI
SARS-CoV-2-specific peripheral T follicular helper cells correlate with neutralizing antibodies and increase during convalescence.
Sushma Boppana,Kai Qin,Jacob K Files,Ronnie M. Russell,Regina Stoltz,Frederic Bibollet-Ruche,Anju Bansal,Nathan Erdmann,Beatrice H. Hahn,Paul A. Goepfert +9 more
TL;DR: CD4 T-cell responses to the M, N, and S structural proteins of SARS-CoV-2 are longitudinally studied, suggesting that M and N protein-specific pTfh may also assist in the development of neutralizing antibodies and that pTFh response formation may be delayed in Sars-Cov-2 infection.
Posted ContentDOI
Antibody Response to a Nucleocapsid Epitope as a Marker for COVID-19 Disease Severity
Sanjana R. Sen,Emily C Sanders,Kristin N Gabriel,Brian M Miller,Hariny M. Isoda,Gabriela S. Salcedo,Jason E Garrido,Rebekah P. Dyer,Rie Nakajima,Aarti Jain,Ana-Maria Caldaruse,Alicia M Santos,Keertna Bhuvan,Delia F. Tifrea,Joni L Ricks-Oddie,Philip L. Felgner,Robert A. Edwards,Sudipta Majumdar,Gregory A. Weiss +18 more
TL;DR: Antibodies targeting a specific location within a SARS-CoV-2 structural protein are linked to poor COVID-19 disease outcomes, and the results lay the groundwork for a new type of CO VID-19 diagnostic for the early prediction of disease severity to guide more effective therapeutic interventions.
Posted ContentDOI
Predicting COVID-19 Severity with a Specific Nucleocapsid Antibody plus Disease Risk Factor Score.
Sanjana R. Sen,Emily C Sanders,Kristin N. Gabriel,Brian M Miller,Hariny M. Isoda,Gabriela S. Salcedo,Jason E Garrido,Rebekah P. Dyer,Rie Nakajima,Aarti Jain,Ana Maria Caldaruse,Alicia M Santos,Keertna Bhuvan,Delia F. Tifrea,Joni L Ricks-Oddie,Philip L. Felgner,Robert A. Edwards,Sudipta Majumdar,Gregory A. Weiss +18 more
TL;DR: In this paper, a simple-to-calculate, disease risk factor score was introduced to quantitate each patients comorbidities and age for predicting COVID-19 disease trajectories.