Adaptive immune responses to SARS-CoV-2.
TLDR
In this paper, a review of adaptive immune responses against SARS-CoV-2, the coronavirus that causes COVID-19, is presented, focusing on the role of antibody and T-cell responses.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2021-05-01 and is currently open access. It has received 6 citations till now. The article focuses on the topics: Immune system.read more
Citations
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SARS‐CoV‐2 memory B and T cell profiles in mild COVID‐19 convalescent patients
Polina Sonis,Mark Dolev,Shay Menascu,Jorge Daniel Czajkowski,R. T. Pardasani,Ohiniko M. Toffa,Zuobing Xiao,Ina Nietzschmann,Richard Schwens +8 more
TL;DR: In this article , a cross-sectional and longitudinal study, blood-derived MBC and MTC responses were evaluated in 68 anti-spike IgG-positive mild coronavirus disease 2019 (COVID-19) convalescents at visit 1, between 1 and 7 months (median 4.1 months) after disease onset.
Journal ArticleDOI
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection
TL;DR: How cellular immunity is the axis around which the rest of the immune system components revolve is discussed, since it orchestrates and leads antiviral response by regulating the inflammatory cascade and, as a consequence, the innate immune system, as well as promoting a correct humoral response through CD4+ Tfh cells.
Journal ArticleDOI
BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and Andes orthohantavirus
Jorge A. Soto,Fabián E. Díaz,Angello Retamal-Díaz,Nicolás M. S. Gálvez,Felipe Melo-Gonzalez,Alejandro Piña-Iturbe,Mario A. Ramirez,Karen Bohmwald,Pablo A. González,Susan M. Bueno,Alexis M. Kalergis +10 more
TL;DR: The BCG vaccine is a promising platform for developing vaccines against different pathogens, inducing a marked antigen-specific immune response, and related to a trained immunity profile.
Journal ArticleDOI
When RING finger family proteins meet SARS‐CoV‐2
TL;DR: Understanding the crosstalk between RNF proteins and SARS‐CoV‐2 infection would help design potential novel targets for COVID‐19 treatment and discuss the diverse antiviral mechanisms of R NF proteins and viral immune evasion in an RNF protein‐dependent manner.
Journal ArticleDOI
Developing dendritic cell for SARS-CoV-2 vaccine: Breakthrough in the pandemic
TL;DR: A dendritic cell-based vaccine for SARS-CoV-2 has the potential to be an effective vaccine that solves existing problems and is summarized by summarizing the crucial role of dendedritic cells in the formation of T cell immunity.
References
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The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients.
Lakshmanane Premkumar,Bruno Segovia-Chumbez,Ramesh Jadi,David R. Martinez,Rajendra Raut,Alena J. Markmann,Caleb Cornaby,Luther A. Bartelt,Susan R. Weiss,Yara A. Park,Caitlin E. Edwards,Eric T. Weimer,Erin M. Scherer,Nadine Rouphael,Srilatha Edupuganti,Daniela Weiskopf,Longping V. Tse,Yixuan J. Hou,David M. Margolis,Alessandro Sette,Alessandro Sette,Matthew H. Collins,John L. Schmitz,Ralph S. Baric,Aravinda M. de Silva +24 more
TL;DR: Results, which reveal the early kinetics of Sars-CoV-2 antibody responses, support using the RBD antigen in serological diagnostic assays and RBD-specific antibody levels as a correlate of SARS-Co V-2 neutralizing antibodies in people.
Journal ArticleDOI
A dynamic COVID-19 immune signature includes associations with poor prognosis.
Adam Laing,Anna Lorenc,Irene del Molino del Barrio,Irene del Molino del Barrio,Abhishek Das,Abhishek Das,Matthew Fish,Matthew Fish,Leticia Monin,Miguel Muñoz-Ruiz,Duncan R. McKenzie,Thomas Hayday,Isaac Francos-Quijorna,Shraddha Kamdar,Magdalene Joseph,Daniel Davies,Daniel Davies,Richard Davis,Aislinn Jennings,Aislinn Jennings,Iva Zlatareva,Pierre Vantourout,Yin Wu,Yin Wu,Yin Wu,Vasiliki Sofra,Florencia Cano,Maria Greco,Efstathios Theodoridis,Joshua D. Freedman,Sarah Gee,Julie Nuo En Chan,Sarah Ryan,Eva Bugallo-Blanco,Pärt Peterson,Kai Kisand,Liis Haljasmägi,Loubna Chadli,Philippe Moingeon,Lauren Martinez,Blair Merrick,Karen Bisnauthsing,Kate Brooks,Mohammad A. A. Ibrahim,Jeremy Mason,Federico Lopez Gomez,Kola Babalola,Sultan Abdul-Jawad,John Cason,Christine Mant,Jeffrey Seow,Carl Graham,Katie J. Doores,Francesca Di Rosa,Jonathan D. Edgeworth,Manu Shankar-Hari,Manu Shankar-Hari,Adrian Hayday,Adrian Hayday +58 more
TL;DR: A core peripheral blood immune signature is identified across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous and sheds light into the pathogenesis and clinical progression of the disease.
Journal ArticleDOI
Risk factors in dengue shock syndrome: a prospective epidemiologic study in rayong, thailand i. the 1980 outbreak
Nadhirat Sangkawibha,Suntharee Rojanasuphot,Sompop Ahandrik,Sukho Viriyapongse,Sujarti Jatanasen,Viraj Salitul,Boonluan Phanthumachinda,Scott B. Halstead +7 more
TL;DR: The municipal area of Rayong, Thailand, and contiguous suburban villages were chosen for a long-term study on dengue epidemiology and the population prevalence of neutralizing antibody to the four d Dengue serotypes was estimated, finding that children with this immunologic background contributed disproportionately to shock cases.
Journal ArticleDOI
T cell responses in patients with COVID-19.
Zeyu Chen,E. John Wherry +1 more
TL;DR: Early reports of the T cell responses observed in patients with COVID-19 are summarized, emphasizing how different immune response characteristics in different patients may reflect a spectrum of disease phenotypes.
Journal ArticleDOI
Comprehensive mapping of immune perturbations associated with severe COVID-19.
Leticia Kuri-Cervantes,M. Betina Pampena,Wenzhao Meng,Aaron M. Rosenfeld,Caroline A. G. Ittner,Ariel R. Weisman,R.S. Agyekum,Divij Mathew,Amy E. Baxter,Laura A. Vella,Laura A. Vella,Oliva Kuthuru,Sokratis A. Apostolidis,Sokratis A. Apostolidis,Luanne Bershaw,Jeanette Dougherty,Allison R. Greenplate,Ajinkya Pattekar,Ajinkya Pattekar,Justin Kim,Nicholas Han,Sigrid Gouma,Madison E. Weirick,Claudia P. Arevalo,Marcus J. Bolton,Eileen C. Goodwin,Elizabeth M. Anderson,Scott E. Hensley,Tiffanie K. Jones,Nilam S. Mangalmurti,Eline T. Luning Prak,E. John Wherry,Nuala J. Meyer,Michael R. Betts +33 more
TL;DR: The neutrophil to lymphocyte ratio is found to be a prognostic biomarker of disease severity and organ failure and broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.