Adaptive immune responses to SARS-CoV-2.
TLDR
In this paper, a review of adaptive immune responses against SARS-CoV-2, the coronavirus that causes COVID-19, is presented, focusing on the role of antibody and T-cell responses.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2021-05-01 and is currently open access. It has received 6 citations till now. The article focuses on the topics: Immune system.read more
Citations
More filters
Journal ArticleDOI
SARS‐CoV‐2 memory B and T cell profiles in mild COVID‐19 convalescent patients
Polina Sonis,Mark Dolev,Shay Menascu,Jorge Daniel Czajkowski,R. T. Pardasani,Ohiniko M. Toffa,Zuobing Xiao,Ina Nietzschmann,Richard Schwens +8 more
TL;DR: In this article , a cross-sectional and longitudinal study, blood-derived MBC and MTC responses were evaluated in 68 anti-spike IgG-positive mild coronavirus disease 2019 (COVID-19) convalescents at visit 1, between 1 and 7 months (median 4.1 months) after disease onset.
Journal ArticleDOI
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection
TL;DR: How cellular immunity is the axis around which the rest of the immune system components revolve is discussed, since it orchestrates and leads antiviral response by regulating the inflammatory cascade and, as a consequence, the innate immune system, as well as promoting a correct humoral response through CD4+ Tfh cells.
Journal ArticleDOI
BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and Andes orthohantavirus
Jorge A. Soto,Fabián E. Díaz,Angello Retamal-Díaz,Nicolás M. S. Gálvez,Felipe Melo-Gonzalez,Alejandro Piña-Iturbe,Mario A. Ramirez,Karen Bohmwald,Pablo A. González,Susan M. Bueno,Alexis M. Kalergis +10 more
TL;DR: The BCG vaccine is a promising platform for developing vaccines against different pathogens, inducing a marked antigen-specific immune response, and related to a trained immunity profile.
Journal ArticleDOI
When RING finger family proteins meet SARS‐CoV‐2
TL;DR: Understanding the crosstalk between RNF proteins and SARS‐CoV‐2 infection would help design potential novel targets for COVID‐19 treatment and discuss the diverse antiviral mechanisms of R NF proteins and viral immune evasion in an RNF protein‐dependent manner.
Journal ArticleDOI
Developing dendritic cell for SARS-CoV-2 vaccine: Breakthrough in the pandemic
TL;DR: A dendritic cell-based vaccine for SARS-CoV-2 has the potential to be an effective vaccine that solves existing problems and is summarized by summarizing the crucial role of dendedritic cells in the formation of T cell immunity.
References
More filters
Journal ArticleDOI
SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescence.
Sushma Boppana,Kai Qin,Jacob K Files,Ronnie M. Russell,Regina Stoltz,Frederic Bibollet-Ruche,Anju Bansal,Nathan Erdmann,Beatrice H. Hahn,Paul A. Goepfert +9 more
TL;DR: In this article, the authors studied CD4 T-cell responses to the M, N, and S structural proteins of SARS-CoV-2 in 26 convalescent individuals.
Journal ArticleDOI
Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity.
TL;DR: There was a strong correlation between IgG avidity and days since symptom onset, and peak readings were significantly higher in severe than mild disease cases.
Posted ContentDOI
A consensus Covid-19 immune signature combines immuno-protection with discrete sepsis-like traits associated with poor prognosis
Adam Laing,Anna Lorenc,Irene del Molino del Barrio,Abhishek Das,Matthew Fish,Leticia Monin,Miguel Muñoz-Ruiz,Duncan R. McKenzie,Thomas Hayday,Isaac Francos Quijorna,Shraddha Kamdar,Magdalene Joseph,Daniel Davies,Richard Davis,Aislinn Jennings,Iva Zlatareva,Pierre Vantourout,Yin Wu,Vasiliki Sofra,Florencia Cano,Maria Greco,Efstathios Theodoridis,Joshua D. Freedman,Sarah Gee,Chan Julie Nuo En,Sarah Ryan,Eva Bugallo Blanco,Pärt Peterson,Kai Kisand,Liis Haljasmägi,Lauren Martinez,Blair Merrick,Karen Bisnauthsing,Kate Brooks,Mohammad A. A. Ibrahim,Jeremy Mason,Federico Lopez Gomez,Kola Babalola,Sultan Abdul Jawad,John Cason,Christine Mant,Katie J. Doores,Jeffrey Seow,Carl Graham,Francesca Di Rosa,Jonathan D. Edgeworth,Manu Shankar Hari,Adrian Hayday +47 more
TL;DR: A consensus peripheral blood immune signature is identified across 63 hospital-treated Covid-19 patients who were otherwise highly heterogeneous, collectively composing a resource to inform SARS-CoV-2 pathobiology and risk-based patient stratification.
Journal ArticleDOI
Pathogenesis of oral type I feline infectious peritonitis virus (FIPV) infection: Antibody-dependent enhancement infection of cats with type I FIPV via the oral route.
TL;DR: Type I FIPV which orally infected cats may cause FIP depending on the condition, and FIP was caused at a 50% probability, i.e. FIP not causing FIP through oral infection caused FIP by inducing antibody-dependent enhancement.
Journal ArticleDOI
Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients.
Anwar M. Hashem,Abdullah Algaissi,Sarah A Almahboub,Mohamed A. Alfaleh,Turki S. Abujamel,Sawsan S. Al-amri,Khalid A Alluhaybi,Haya I. Hobani,Rahaf H. Alharbi,Reem M. Alsulaiman,M-Zaki ElAssouli,Sharif Hala,Naif Khalaf Alharbi,Rowa Y. Alhabbab,Ahdab AlSaieedi,Wesam H. Abdulaal,Abdullah Bukhari,Afrah Alsomali,Fadwa S. Alofi,Asim Khogeer,Arnab Pain,Almohanad A. Alkayyal,Naif A.M. Almontashiri,Bakur Mahmoud Ahmad,Xuguang Li +24 more
TL;DR: Investigating the kinetics of IgM, IgG against the spike (S) and nucleoproteins (N) proteins and their neutralizing capabilities in hospitalized COVID-19 patients with different disease presentations found that the levels of anti-N antibodies correlated strongly with disease severity.