Adaptive immune responses to SARS-CoV-2.
TLDR
In this paper, a review of adaptive immune responses against SARS-CoV-2, the coronavirus that causes COVID-19, is presented, focusing on the role of antibody and T-cell responses.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2021-05-01 and is currently open access. It has received 6 citations till now. The article focuses on the topics: Immune system.read more
Citations
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SARS‐CoV‐2 memory B and T cell profiles in mild COVID‐19 convalescent patients
Polina Sonis,Mark Dolev,Shay Menascu,Jorge Daniel Czajkowski,R. T. Pardasani,Ohiniko M. Toffa,Zuobing Xiao,Ina Nietzschmann,Richard Schwens +8 more
TL;DR: In this article , a cross-sectional and longitudinal study, blood-derived MBC and MTC responses were evaluated in 68 anti-spike IgG-positive mild coronavirus disease 2019 (COVID-19) convalescents at visit 1, between 1 and 7 months (median 4.1 months) after disease onset.
Journal ArticleDOI
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection
TL;DR: How cellular immunity is the axis around which the rest of the immune system components revolve is discussed, since it orchestrates and leads antiviral response by regulating the inflammatory cascade and, as a consequence, the innate immune system, as well as promoting a correct humoral response through CD4+ Tfh cells.
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BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and Andes orthohantavirus
Jorge A. Soto,Fabián E. Díaz,Angello Retamal-Díaz,Nicolás M. S. Gálvez,Felipe Melo-Gonzalez,Alejandro Piña-Iturbe,Mario A. Ramirez,Karen Bohmwald,Pablo A. González,Susan M. Bueno,Alexis M. Kalergis +10 more
TL;DR: The BCG vaccine is a promising platform for developing vaccines against different pathogens, inducing a marked antigen-specific immune response, and related to a trained immunity profile.
Journal ArticleDOI
When RING finger family proteins meet SARS‐CoV‐2
TL;DR: Understanding the crosstalk between RNF proteins and SARS‐CoV‐2 infection would help design potential novel targets for COVID‐19 treatment and discuss the diverse antiviral mechanisms of R NF proteins and viral immune evasion in an RNF protein‐dependent manner.
Journal ArticleDOI
Developing dendritic cell for SARS-CoV-2 vaccine: Breakthrough in the pandemic
TL;DR: A dendritic cell-based vaccine for SARS-CoV-2 has the potential to be an effective vaccine that solves existing problems and is summarized by summarizing the crucial role of dendedritic cells in the formation of T cell immunity.
References
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Journal ArticleDOI
Optimized Pseudotyping Conditions for the SARS-COV-2 Spike Glycoprotein.
Marc C. Johnson,Terri D. Lyddon,Reinier Suarez,Braxton Salcedo,Mary LePique,Maddie Graham,Clifton L. Ricana,Carolyn A. Robinson,Detlef Ritter +8 more
TL;DR: In this article, a codon-optimized SARS-COV-2 Spike glycoprotein was used for the generation of pseudotyped HIV-1, murine leukemia virus (MLV), and vesicular stomatitis virus (VSV) particles.
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Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19.
Hongyan Hou,Bo Zhang,H. Huang,Ying Luo,Shiji Wu,Guoxing Tang,Weiyong Liu,Liyan Mao,Feng Wang,Ziyong Sun +9 more
TL;DR: The IL‐2R/lymphocyte was a prominent biomarker for early identification of severe COVID‐19 and predicting the clinical progression of the disease.
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Anti-SARS-CoV IgG response in relation to disease severity of severe acute respiratory syndrome.
Nelson Lee,Paul K.S. Chan,Margaret Ip,Eric Wong,Jenny Ho,Catherine W. Ho,Clive S. Cockram,David S.C. Hui +7 more
TL;DR: A retrospective analysis of all acute and convalescent-phase sera collected from a cohort of laboratory-confirmed SARS cases to study seroconversion and the magnitude of IgG responses in a SARS cohort with different disease severities.
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Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals.
Fang Gong,Yaping Dai,Ting Zheng,Liang Cheng,Dan Zhao,Hao Wang,Min Liu,Hao Pei,Tengchuan Jin,Di Yu,Pengcheng Zhou +10 more
TL;DR: This study demonstrated close connection between CD4+ T cells and antibody production in COVID-19 convalescents, and found the highest ratio of class-switched virus-specific antibody producing individuals found in this severe CO VID-19 cohort.
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Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2–Specific IgG
Sina Schwarzkopf,Adalbert Krawczyk,Dietmar Knop,Hannes Klump,Andreas Heinold,Falko M. Heinemann,Laura Thümmler,Christian Temme,Marianne Breyer,Oliver Witzke,Ulf Dittmer,Veronika Lenz,Peter A. Horn,Monika Lindemann +13 more
TL;DR: It is concluded that, in convalescent patients with undetectable SARS-CoV-2 IgG, immunity may be mediated through T cells, and a similar frequency of T-cell immunity in Convalescent donors with strong antibody responses but did not detect immunity in negative controls.