Adhesion of osteoblasts to a nanorough titanium implant surface
Ekaterina Gongadze,Doron Kabaso,Sebastian Bauer,Tomaž Slivnik,Patrik Schmuki,Ursula van Rienen,Aleš Iglič +6 more
Reads0
Chats0
TLDR
It is suggested that osteoblasts are most strongly bound along the sharp convex edges or spikes of nanorough titanium surfaces where the magnitude of the negative surface charge density is the highest and it is plausible that nanorough regions of titanium surfaces with sharp edges and spikes promote the adhesion of osteoblast.Abstract:
This work considers the adhesion of cells to a nanorough titanium implant surface with sharp edges. The basic assumption was that the attraction between the negatively charged titanium surface and a negatively charged osteoblast is mediated by charged proteins with a distinctive quadrupolar internal charge distribution. Similarly, cation-mediated attraction between fibronectin molecules and the titanium surface is expected to be more efficient for a high surface charge density, resulting in facilitated integrin mediated osteoblast adhesion. We suggest that osteoblasts are most strongly bound along the sharp convex edges or spikes of nanorough titanium surfaces where the magnitude of the negative surface charge density is the highest. It is therefore plausible that nanorough regions of titanium surfaces with sharp edges and spikes promote the adhesion of osteoblasts.read more
Citations
More filters
Journal ArticleDOI
Light controlled metallo-drug delivery system based on the TiO2-nanoparticles and Ru-complex
Maja Nešić,Jelena Žakula,Lela Korićanac,Milutin Stepić,Marija Radoičić,Iva Popović,Zoran Šaponjić,Marijana Petković +7 more
TL;DR: The colloidal TiO 2 nanoparticles studied as a carrier for controlled delivery of the ruthenium complex to the melanoma cell line demonstrated light–dependent cytotoxicity, which might be of interest for development of new more efficient drug delivery approaches by using a light as external stimulus.
Journal ArticleDOI
Surface Characterization and Biocompatibility of Hydroxyapatite Coating on Anodized TiO2 Nanotubes via PVD Magnetron Sputtering.
TL;DR: MTS assay using osteoblast-like cells confirmed that the HA-coated TiO2 nanotubular surface provided an enhanced cell attachment and growth when compared to as-anodized TiO1 nanotUBular and pure CP-Ti surfaces.
Journal ArticleDOI
Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation.
Angelamaria Cardone,Jie Sun,Yingkang Huang,David Feldman,David Feldman,Huan Zhao,Junjie Niu,Xuwei Ling,Can Zhu,Lin Wang,Huilin Yang,Zhilu Yang,Guoqing Pan,Qin Shi +13 more
TL;DR: Wang et al. as discussed by the authors designed clickable mussel-inspired peptides (DOPA-N3) and grafted them onto the surfaces of Ti materials through robust catechol-TiO2 coordinative interactions.
Journal ArticleDOI
Antibacterial composite hybrid coatings of veterinary medical implants.
Magdalena Ziąbka,Joanna Kiszka,Anita Trenczek-Zając,Marta Radecka,Katarzyna Cholewa-Kowalska,Igor Bissenik,Agnieszka Kyzioł,Michal Dziadek,Michal Dziadek,Wiktor Niemiec,Aleksandra Królicka +10 more
TL;DR: The results confirmed that the hybrid antibacterial layers effectively protected the implant surface against scratches and corrosion and eliminated bacteria, which would promote bone healing and raise hopes for their applicability in the veterinary treatment of bone fractures.
Journal ArticleDOI
Low fibronectin concentration overcompensates for reduced initial fibroblasts adhesion to a nanoscale topography: Single-cell force spectroscopy
TL;DR: It is demonstrated that cell adhesion is influenced by substrate topography and fibronectin, which mediate the interplay between specific interactions, non-specific interactions, and cell mechanics.
References
More filters
Book
Intermolecular and surface forces
TL;DR: The forces between atoms and molecules are discussed in detail in this article, including the van der Waals forces between surfaces, and the forces between particles and surfaces, as well as their interactions with other forces.
Journal ArticleDOI
RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
TL;DR: The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed.
Journal ArticleDOI
Exploring and engineering the cell surface interface.
TL;DR: Current approaches to control cell behavior through the nanoscale engineering of materials surfaces are reviewed and implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration.
Journal ArticleDOI
Osteoblast adhesion on biomaterials.
TL;DR: An understanding of the proteins involved in osteoblast adhesion opens up new possibilities for the grafting of these proteins (or synthesized peptide) onto vector materials, to increase their in vivo bioactivity or to promote cell integration within the vector material during the development of hybrid materials.