Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China
Jie-Ming Qu,Jing Zhang,Yu Chen,Yi Huang,Yusang Xie,Min Zhou,Yuping Li,Dongwei Shi,Jinfu Xu,Qiuyue Wang,Bei He,Ning Shen,Bin Cao,Danyang She,Yi Shi,Xin Su,Hua Zhou,Hong Fan,Feng Ye,Qiao Zhang,Xinlun Tian,Guoxiang Lai +21 more
TLDR
Early combined detection increased the pathogen identification rate and possibly benefitted survival in SCAP patients in China, and Physicians should be aware of the emergence of uncommon pathogens, including Chlamydia Psittaci and Leptospira.Abstract:
ABSTRACT Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged in the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS in SCAP pathogen identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre prospective study in 17 hospitals of SCAP patients within 48 hours of emergency room stay or hospitalization in China. All clinical data were uploaded into an online database. Blood, urine and respiratory specimens were collected for routine culture, antigen detection, PCR and mNGS as designed appropriately. Aetiology confirmation was made by the local attending physician group and scientific committee according to microbiological results, clinical features, and response to the treatment. Two hundred seventy-five patients were included for final analysis. Combined detection methods made identification rate up to 74.2% (222/299), while 14.4% (43/299) when only using routine cultures and 40.8% (122/299) when not using mNGS. Influenza virus (23.2%, 46/198), S. pneumoniae (19.6%, 39/198), Enterobacteriaceae (14.6%, 29/198), Legionella pneumophila (12.6%, 25/198), Mycoplasma pneumoniae (11.1%, 22/198) were the top five common pathogens. The in-hospital mortality of patients with pathogen identified and unidentified was 21.7% (43/198) and 25.9% (20/77), respectively. In conclusion, early combined detection increased the pathogen identification rate and possibly benefitted survival. Influenza virus, S. pneumoniae, Enterobacteriaceae was the leading cause of SCAP in China, and there was a clear seasonal distribution pattern of influenza viruses. Physicians should be aware of the emergence of uncommon pathogens, including Chlamydia Psittaci and Leptospira.read more
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Comparative analysis of the lung microbiota in patients with respiratory infections, tuberculosis, and lung cancer: A preliminary study
Xiaoxue Xia,Jiang Chen,Yiwen Cheng,Feng Chen,Huoquan Lu,Jianfeng Liu,Ling Wang,Fengxia Pu,Ying Wang,Huan Liu,Daxing Cao,Zhengye Zhang,Zeping Xia,Meili Fan,Zong Ya Ling,Longyou Zhao +15 more
TL;DR: In this article , the authors compared the lung microbiota and lung immune profiles in common respiratory diseases, including 21 patients with primary pulmonary tuberculosis (PTB), eight patients with newly diagnosed lung cancer (LC), and 49 patients with community-acquired pneumonia (CAP).
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Clinical characteristics of the host DNA-removed metagenomic next-generation sequencing technology for detecting SARS-CoV-2, revealing host local immune signaling and assisting genomic epidemiology
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TL;DR: In this paper , the authors evaluated the clinical characteristics of the host DNA-removed mNGS technology for detecting SARS-CoV-2, revealing host local immune signaling and assisting genomic epidemiology.
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Metagenomic next‑generation sequencing of BALF for the clinical diagnosis of severe community‑acquired pneumonia in immunocompromised patients: A single‑center study.
TL;DR: Wang et al. as mentioned in this paper investigated the value of mNGS compared with conventional microbiological tests (CMTs) in the clinical diagnosis of severe community-acquired pneumonia (SCAP) in immunocompromised individuals.
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Prevalence and molecular characteristics of community-associated methicillin-resistant Staphylococcus aureus in the respiratory tracts of Chinese adults with community-acquired pneumonia.
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The CREPE Score: A Predictive Tool for Third-Generation Cephalosporin-Resistant Enterobacterales Pneumonia in Community Settings
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TL;DR: In this paper , the authors evaluated risk factors and developed a prediction score for community-acquired pneumonia caused by third-generation cephalosporin-resistant enterobacterales (3GCR EB-CAP).
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