Affinity and specificity of motif-based protein-protein interactions
Ylva Ivarsson,Per Jemth +1 more
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TLDR
Recent advances in molecular aspects of affinity and specificity in protein-protein interactions involving disordered protein regions are reviewed.About:
This article is published in Current Opinion in Structural Biology.The article was published on 2019-02-01 and is currently open access. It has received 78 citations till now. The article focuses on the topics: Binding site & Protein–protein interaction.read more
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MobiDB: intrinsically disordered proteins in 2021.
Damiano Piovesan,Marco Necci,Nahuel Escobedo,Alexander Miguel Monzon,András Hatos,Ivan Mičetić,Federica Quaglia,Lisanna Paladin,Pathmanaban Ramasamy,Zsuzsanna Dosztányi,Wim F. Vranken,Norman E. Davey,Gustavo Parisi,Monika Fuxreiter,Silvio C. E. Tosatto +14 more
TL;DR: The new MobiDB version presents state-of-the-art knowledge on disordered proteins and improves data accessibility for both computational and experimental users.
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Interactions by Disorder - A Matter of Context.
Katrine Bugge,Inna Brakti,Catarina B. Fernandes,Jesper E Dreier,Jeppe E. Lundsgaard,Johan G. Olsen,Karen Skriver,Birthe B. Kragelund +7 more
TL;DR: This review emphasizes how multivalency, charges and charge clusters, hydrophobic patches, dynamics, energetic frustration, and ensemble redistribution of flanking regions or disordered contexts are emerging as important contributors to allosteric regulation, positive and negative cooperativity, feedback regulation and negative selection in binding.
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The functional importance of structure in unstructured protein regions.
TL;DR: The current understanding of different types of intramolecular IDR interactions, their effects on IDR complex formation and their modes of biological regulation are reviewed.
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The pathobiology of perturbed mutant huntingtin protein-protein interactions in Huntington's disease.
TL;DR: This review focuses on abnormal PPIs that are associated with the assembly of mutant HTT aggregates in cells and their potential relevance in disease, and discusses the mechanisms and pathobiological processes that may contribute to phenotype development, neuronal dysfunction and toxicity in Huntington's disease brains.
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Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads.
Huy V. Nguyen,Jagoree Roy,Björn Harink,Nikhil P Damle,Naomi R. Latorraca,Brian Baxter,Kara Brower,Scott A. Longwell,Tanja Kortemme,Kurt S. Thorn,Martha S. Cyert,Polly M. Fordyce +11 more
TL;DR: This work systematically probes binding of calcineurin (CN), a conserved protein phosphatase essential for the immune response and target of immunosuppressants, and discovers that flanking residues and post-translational modifications critically contribute to PxIxIT-CN affinity.
References
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Journal ArticleDOI
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Andrew J. Souers,Joel D. Leverson,Erwin R. Boghaert,Scott L. Ackler,Nathaniel D. Catron,Jun Chen,Brian D. Dayton,Hong Ding,Sari H. Enschede,Wayne J. Fairbrother,David C.S. Huang,David C.S. Huang,Sarah G. Hymowitz,Sha Jin,Seong Lin Khaw,Seong Lin Khaw,Peter Kovar,Lloyd T. Lam,Jackie Lee,Heather Maecker,Kennan C. Marsh,Kylie D. Mason,Kylie D. Mason,Kylie D. Mason,Michael J. Mitten,Paul Nimmer,Anatol Oleksijew,Chang H. Park,Cheol-Min Park,Cheol-Min Park,Darren C. Phillips,Andrew W. Roberts,Andrew W. Roberts,Andrew W. Roberts,Deepak Sampath,John F. Seymour,John F. Seymour,Morey L. Smith,Gerard M. Sullivan,Stephen K. Tahir,Chris Tse,Michael D. Wendt,Yu Xiao,John Xue,Haichao Zhang,Rod A. Humerickhouse,Saul H. Rosenberg,Steven W. Elmore +47 more
TL;DR: The re-engineering of navitoclax is reported to create a highly potent, orally bioavailable and BCL-2–selective inhibitor, ABT-199, which inhibits the growth of BCL–dependent tumors in vivo and spares human platelets, indicating that selective pharmacological inhibition of Bcl-2 shows promise for the treatment of B CL-2-dependent hematological cancers.
Journal ArticleDOI
Intrinsically disordered proteins in cellular signalling and regulation.
Peter E. Wright,H. Jane Dyson +1 more
TL;DR: Experimental, computational and bioinformatic analyses combine to identify and characterize disordered regions of proteins, leading to a greater appreciation of their widespread roles in biological processes.
Journal ArticleDOI
Transcriptional activation by recruitment
Mark Ptashne,Alexander Gann +1 more
TL;DR: Findings from experiments in bacteria and yeast indicate that many genes can be activated by the recruitment model for gene activation, and for the role of histones in gene regulation.
Journal ArticleDOI
A conserved docking motif in MAP kinases common to substrates, activators and regulators
TL;DR: A hitherto unidentified docking motif in MAPKs is revealed that is used in common for recognition of their activators, substrates and regulators and increases the efficiency of the enzymatic reactions.
Journal ArticleDOI
Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information
TL;DR: Although most scaffolds use a simple tethering mechanism to increase the efficiency of interaction between individual partner molecules, these proteins can also exert complex allosteric control over their partners and are themselves the target of regulation.