Journal ArticleDOI
Aldehyde dehydrogenase 1 expression predicts poor prognosis in triple‐negative breast cancer
Yasuyo Ohi,Yoshihisa Umekita,Takako Yoshioka,Masakazu Souda,Yoshiaki Rai,Yoshiaki Sagara,Yasuaki Sagara,Yoshiatsu Sagara,Akihide Tanimoto +8 more
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Ohi Y, Umekita Y, Yoshioka T, Souda M, Rai Y, Sagara Y, sagara Y & Tanimoto A
(2011) Histopathology59, 776–780.Abstract:
Ohi Y, Umekita Y, Yoshioka T, Souda M, Rai Y, Sagara Y, Sagara Y, Sagara Y & Tanimoto A (2011) Histopathology59, 776–780
Aldehyde dehydrogenase 1 expression predicts poor prognosis in triple-negative breast cancer
Aims: Aldehyde dehydrogenase 1 (ALDH1) has been identified as a reliable marker of breast cancer stem cells, and its clinical significance as a prognostic indicator of breast cancer has been reported by several investigators. However, the clinical significance of ALDH1 expression in triple-negative (TN) breast cancer, a high-risk breast cancer lacking the benefit of specific therapy, remains to be solved.
Methods and results: We performed immunohistochemical analyses of 106 TN breast cancers, using paraffin-embedded sections. The basal-like phenotype was also investigated with the use of basal cytokeratin 5/6 and epidermal growth factor receptor. ALDH1 expression in carcinoma cells was found in 59% of cases and was correlated with high histological grade alone (P < 0.006), whereas ALDH1 expression in stromal cells was found in 49% of cases but was not correlated with any clinicopathological parameter. Patients with ALDH1 expression in carcinoma cells had a shorter relapse-free survival (RFS) according to the log-rank test (P = 0.015). According to Cox multivariate analysis, ALDH1 expression in carcinoma cells was an independent prognostic indicator of RFS (P = 0.025). The log-rank test revealed that stromal expression of ALDH1 had no effect on RFS.
Conclusions: ALDH1 expression in carcinoma cells is an independent prognostic factor in TN breast cancer patients.read more
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Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization
Virginia Tirino,Vincenzo Desiderio,Francesca Paino,Alfredo De Rosa,Federica Papaccio,Marcella La Noce,Luigi Laino,Francesco De Francesco,Gianpaolo Papaccio +8 more
TL;DR: An overview of the main characteristics and approaches used to identify, isolate, and characterize cancer stem cells from solid tumors is provided.
Journal ArticleDOI
Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells
Peng Liu,I S Kumar,Sarah Brown,Vinodh Kannappan,Patricia Erebi Tawari,James Z. Tang,Wen Guo Jiang,Angel L. Armesilla,John L. Darling,Weiguang Wang +9 more
TL;DR: Disulfiram abolished CSC characters and completely reversed PAC and CDDP resistance in MDA-MB-231PAC10 cells, suggesting cancer stem cells may be responsible for acquired pan-chemoresistance.
Journal ArticleDOI
Aldehyde dehydrogenases and cancer stem cells.
TL;DR: A review of the function and regulation of ALDHs in CSCs, particularly AL DH1A1 and ALDH1A3, particularly in relation to transcriptional and post-translational regulation.
Journal ArticleDOI
Triple-Negative Breast Cancer: Current Understanding and Future Therapeutic Breakthrough Targeting Cancer Stemness.
TL;DR: The latest evidence concerning the role of genomic alteration in current TNBC treatment responses, current clinical trials and potential targeting sites, CSC and drug resistance, and potential strategies targeting CSCs in TNBC are surveyed.
Journal ArticleDOI
Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer
Maria Papadaki,Galatea Kallergi,Zafeiris Zafeiriou,Lefteris Manouras,Panayiotis A. Theodoropoulos,Dimitris Mavroudis,Vassilis Georgoulias,Sofia Agelaki +7 more
TL;DR: CTCs expressing high ALDH1, along with nuclear TWIST were more frequently detected in patients with metastatic breast cancer, suggesting that these cells may prevail during disease progression.
References
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Journal ArticleDOI
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
Christophe Ginestier,Min Hee Hur,Emmanuelle Charafe-Jauffret,Florence Monville,Julie Dutcher,Marty Brown,Jocelyne Jacquemier,Patrice Viens,Celina G. Kleer,Suling Liu,Anne F. Schott,Daniel F. Hayes,Daniel Birnbaum,Max S. Wicha,Gabriela Dontu +14 more
TL;DR: It is shown that normal and cancer human mammary epithelial cells with increased aldehyde dehydrogenase activity (ALDH) have stem/progenitor properties and these cells contain the subpopulation of normal breast epithelium with the broadest lineage differentiation potential and greatest growth capacity in a xenotransplant model.
Journal ArticleDOI
Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma
Torsten O. Nielsen,Forrest D. Hsu,Kristin C. Jensen,Maggie C.U. Cheang,Gamze Karaca,Zhiyuan Hu,Tina Hernandez-Boussard,Chad A. Livasy,Dave Cowan,Lynn G. Dressler,Lars A. Akslen,Joseph Ragaz,Allen M. Gown,C. Blake Gilks,Matt van de Rijn,Charles M. Perou +15 more
TL;DR: A panel of four antibodies (ER, HER1, HER2, and cytokeratin 5/6) can accurately identify basal-like tumors using standard available clinical tools and shows high specificity.
Journal ArticleDOI
Triple-negative/basal-like breast cancer: review
Emad A. Rakha,Ian O. Ellis +1 more
TL;DR: A better understanding of the molecular and histopathological features of TN and basal‐like cancers is of paramount importance for unravelling the heterogeneous nature of these tumour subgroups and for the identification of prognostic biomarkers, ideal systemic therapy regimens and novel therapeutic targets for these aggressive tumours.
Journal ArticleDOI
Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment.
Erika Resetkova,Jorge S. Reis-Filho,Rohit Jain,Rutika Mehta,Mangesh A. Thorat,Harikrishna Nakshatri,Sunil Badve +6 more
TL;DR: Tumor microenvironment may play a significant role in determining the prognostic impact of stem/progenitor cells in human breast tumors, and high degree of stromal expression was significantly associated with best disease-free survival and a trend for overall survival.
Journal ArticleDOI
Aldehyde dehydrogenase 1 expression is a predictor of poor prognosis in node-positive breast cancers: a long-term follow-up study.
Takako Yoshioka,Yoshihisa Umekita,Yasuyo Ohi,Masakazu Souda,Yoshiatsu Sagara,Yasuaki Sagara,Yoshiaki Sagara,Yoshiaki Rai,Akihide Tanimoto +8 more
TL;DR: Aldehyde dehydrogenase 1 expression is a predictor of poor prognosis in node‐positive breast cancers: a long‐term follow‐up study.
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