Journal ArticleDOI
Altered corticostriatal synchronization associated with compulsive-like behavior in APP/PS1 mice.
Yi-gang Peng,Ping-jing Cai,Jian-hang Hu,Jinxiang Jiang,Jiajia Zhang,Ke-fang Liu,Li Yang,Cheng Long +7 more
TLDR
In this paper, the number of parvalbumin-positive interneurons and level of high gamma (γhigh) oscillation are significantly decreased in the striatum of AD mice, accompanied by enhanced β-γhigh coupling and firing rates of putative striatal projection neurons.About:
This article is published in Experimental Neurology.The article was published on 2021-10-01. It has received 6 citations till now. The article focuses on the topics: Striatum & Prefrontal cortex.read more
Citations
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Journal ArticleDOI
Theta and gamma oscillatory dynamics in mouse models of Alzheimer’s disease: A path to prospective therapeutic intervention
Sonam Fathima Mehak,Apoorva Bettagere Shivakumar,Sparsha Kumari,Bhadra Muralidharan,Gireesh Gangadharan +4 more
TL;DR: In this paper , the authors reviewed the evidence from mouse models that shows how synchronized oscillatory activity is intricately linked to AD machinery, and they primarily focused on recent reports showing abnormal oscillatory activities at theta and gamma frequencies in AD condition and their influence on cellular disturbances and cognitive impairments.
Journal ArticleDOI
Gene Expression Analysis of the Endocannabinoid System in Presymptomatic APP/PS1 Mice
TL;DR: The data indicated that the ECS is already altered in APP/PS1 mice at the presymptomatic stage, suggesting that it could be an early event contributing to the pathophysiology of AD or being a potential predictive biomarker.
Journal ArticleDOI
Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum
TL;DR: In this article , the deubiquitinase cylindromatosis (CYLD), an abundant protein in the postsynaptic density fraction, plays a crucial role in mediating the synaptic activity of the striatum.
Journal ArticleDOI
Amyloid-β Protein Precursor Regulates Electrophysiological Properties in the Hippocampus via Altered Kv1.4 Expression and Function in Mice.
TL;DR: In this paper , the authors explored hippocampal local field potential (LFP) and spiking in the presence and absence of AβPP, and the potential involvement of an A-type potassium channel.
References
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Book
The Mouse Brain in Stereotaxic Coordinates
TL;DR: The 3rd edition of this atlas is now in more practical 14"x11" format for convenient lab use and includes a CD of all plates and diagrams, as well as Adobe Illustrator files of the diagrams, and a variety of additional useful material.
Journal ArticleDOI
Modulation of Oscillatory Neuronal Synchronization by Selective Visual Attention
TL;DR: Neurons activated by the attended stimulus showed increased gamma-frequency but reduced low-frequency synchronization compared with neurons at nearby V4 sites activated by distracters, suggesting localized changes in synchronization may serve to amplify behaviorally relevant signals in the cortex.
Journal ArticleDOI
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Jessica A. Cardin,Marie Carlén,Marie Carlén,Konstantinos Meletis,Konstantinos Meletis,Ulf Knoblich,Feng Zhang,Karl Deisseroth,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai,Christopher I. Moore +11 more
TL;DR: The timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses and provided the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.
Journal ArticleDOI
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
TL;DR: Optogenetics opens the door to a new kind of informational analysis of brain function, permitting quantitative delineation of the functional significance of individual elements in the emergent operation and function of intact neural circuitry.
Journal ArticleDOI
Putting a spin on the dorsal–ventral divide of the striatum
Pieter Voorn,Louk J. M. J. Vanderschuren,Henk J. Groenewegen,Trevor W. Robbins,Cyriel M. A. Pennartz +4 more
TL;DR: This review presents a synthesis between the dorsal-ventral distinction and the more mediolateral-oriented functional striatal gradient.
Related Papers (5)
Strengthened Inputs from Secondary Motor Cortex to Striatum in a Mouse Model of Compulsive Behavior.
Changes in the Prefrontal Glutamatergic and Parvalbumin Systems of Mice Exposed to Unpredictable Chronic Stress
Ryan Shepard,Laurence Coutellier +1 more