Journal ArticleDOI
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
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TLDR
Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2001-05-16. It has received 1367 citations till now. The article focuses on the topics: Amorphous solid & Crystallization.read more
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Factors Contributing to the Glass-Forming Ability of a Simulated Molecular Liquid
Ulf R. Pedersen,Peter Harrowell +1 more
TL;DR: Evidence is presented that enhanced glass-forming ability is due, in equal parts, to the slower dynamics and the larger crystal-liquid interfacial free energy in the molecular liquid.
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Physicochemical Characterization of a Co-Amorphous Atorvastatin-Irbesartan System with a Potential Application in Fixed-Dose Combination Therapy
Marcin Skotnicki,Barbara Jadach,Agnieszka Skotnicka,Bartłomiej Milanowski,Lidia Tajber,Marek Pyda,Jacek Kujawski +6 more
TL;DR: In this article, a 1:1 molar ratio of a pharmacologically relevant co-amorphous atorvastatin-irbesartan (ATR-IRB) system obtained by quench cooling of the crystalline ATR/IRB physical mixture for potential use in the fixed-dose combination therapy was characterized by employing standard differential scanning calorimetry (DSC), Fourier transform-infrared spectroscopy (FT-IR), and intrinsic dissolution rate studies.
Journal ArticleDOI
Disentangling α and β relaxation in orientationally disordered crystals with theory and experiments
TL;DR: The proposed framework brings together all the key aspects of glassy physics (VDOS with the boson peak, dynamical heterogeneity, dissipation, and anharmonicity) into a single model.
Journal ArticleDOI
On the solubility advantage of a pharmaceutical’s glassy state over the crystal state, and of its crystal polymorphs
G. P. Johari,Ravi Mysore Shanker +1 more
TL;DR: In this paper, the authors argue that the ϕcal differs from the measured solubility ratio, ϕmeas, because, (i) ϕCal is independent of the solvent, but ϕMEas is not so, (ii) ρmeas would increase with the dissolution time monotonically to a constant value, and (iii) approximations are made in estimating ρcal and the effect of thermal history on high free energy solids is ignored.
Journal ArticleDOI
Generation of Zwitterionic Water Channels: Biszwitterionic Imidazolium Carboxylates as Hydrogen-Bonding Acceptors
Shigeo Kohmoto,Shinpei Okuyama,Yokota Nobuyuki,Masahiro Takahashi,Keiki Kishikawa,Hyuma Masu,Isao Azumaya +6 more
TL;DR: In this paper, an organic crystal containing several types of water channels is generated by clipping water molecules with biswitterionic imidazolium carboxylates as hydrogen-bonding acceptors.
References
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On the Temperature Dependence of Cooperative Relaxation Properties in Glass‐Forming Liquids
Gerold Adam,Julian H. Gibbs +1 more
TL;DR: In this paper, a molecularkinetic theory was proposed to explain the temperature dependence of relaxation behavior in glass-forming liquids in terms of the temperature variation of the size of the cooperatively rearranging region.
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The theory of transformations in metals and alloys : an advanced textbook in physical metallurgy
Journal ArticleDOI
Formation of glasses from liquids and biopolymers.
TL;DR: The onset of a sharp change in ddT( is the Debye-Waller factor and T is temperature) in proteins, which is controversially indentified with the glass transition in liquids, is shown to be general for glass formers and observable in computer simulations of strong and fragile ionic liquids, where it proves to be close to the experimental glass transition temperature.
Book
The theory of transformations in metals and alloys
J.W. Christian,H. M. Otte +1 more
TL;DR: In this paper, the authors present a general introduction to the theory of transformation kinetics of real metals, including the formation and evolution of martensitic transformations, as well as a theory of dislocations.
Journal ArticleDOI
Nonexponential relaxations in strong and fragile glass formers
TL;DR: In this article, a broad correlation of non-debye behavior with non-Arrhenius relaxations was found for different types of glass formers, distinguished by their respective molecular complexity.
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