Journal ArticleDOI
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
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TLDR
Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2001-05-16. It has received 1367 citations till now. The article focuses on the topics: Amorphous solid & Crystallization.read more
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Book ChapterDOI
Spray drying and amorphous dispersions
Kristin J. M. Ploeger,Paige Adack,Pavithra Sundararajan,P. C. Valente,João G. Henriques,Kenneth J. Rosenberg +5 more
Journal ArticleDOI
Insights into co-amorphous systems in therapeutic drug delivery.
TL;DR: This review covers the fundamentals of CAM systems and recent advances in formulation development, and strives to address the theoretical, molecular, technical and biopharmaceutical aspects, advantages over polymeric amorphous solid dispersions, mechanisms of stabilization ofAmorphous forms, insights into unexplored in silico tools in excipient selection and regulatory viewpoints.
Journal ArticleDOI
Molecular Mobility of Terfenadine: Investigation by Dielectric Relaxation Spectroscopy and Molecular Dynamics Simulation.
TL;DR: Terfenadine exhibits an enhanced main mobility induced by an auto-confinement effect created by the surrounding crystalline phase, and is one of the very few cases for which the molecular mobility of the glass obtained by quench of the melt or by milling can be compared.
Journal ArticleDOI
Preparation and Characterization of Silymarin Nanocrystals and Phytosomes with Investigation of their Stability using Gamma Irradiation
TL;DR: Nanocrystals and phytosomes could be considered as successful strategies for enhancing properties of Silymarin, and may be used as sustained release after radiation and noted that, the two dissolution formulations exhibited highest dissolution profile.
Journal ArticleDOI
Enzyme Retention During Drying of Amorphous Sugar and Carbohydrate Solutions: Diffusion Model Revisited
TL;DR: In this article, the authors investigated enzyme retention during drying of amorphous sugar and carbohydrate solutions based on the diffusion model and found that enzymes become stable at lower water contents, and high enzyme retention is possible when the drying condition is tuned.
References
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Journal ArticleDOI
On the Temperature Dependence of Cooperative Relaxation Properties in Glass‐Forming Liquids
Gerold Adam,Julian H. Gibbs +1 more
TL;DR: In this paper, a molecularkinetic theory was proposed to explain the temperature dependence of relaxation behavior in glass-forming liquids in terms of the temperature variation of the size of the cooperatively rearranging region.
Book
The theory of transformations in metals and alloys : an advanced textbook in physical metallurgy
Journal ArticleDOI
Formation of glasses from liquids and biopolymers.
TL;DR: The onset of a sharp change in ddT( is the Debye-Waller factor and T is temperature) in proteins, which is controversially indentified with the glass transition in liquids, is shown to be general for glass formers and observable in computer simulations of strong and fragile ionic liquids, where it proves to be close to the experimental glass transition temperature.
Book
The theory of transformations in metals and alloys
J.W. Christian,H. M. Otte +1 more
TL;DR: In this paper, the authors present a general introduction to the theory of transformation kinetics of real metals, including the formation and evolution of martensitic transformations, as well as a theory of dislocations.
Journal ArticleDOI
Nonexponential relaxations in strong and fragile glass formers
TL;DR: In this article, a broad correlation of non-debye behavior with non-Arrhenius relaxations was found for different types of glass formers, distinguished by their respective molecular complexity.
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