Journal ArticleDOI
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
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TLDR
Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2001-05-16. It has received 1367 citations till now. The article focuses on the topics: Amorphous solid & Crystallization.read more
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Ibrutinib and carboxylic acid coamorphous system with increased solubility and dissolution: A potential interaction mechanism
TL;DR: In this paper, the authors investigated the interaction mechanism between Ibrutinib and acids responsible for enhancement and showed that coamorphization of IBR and acid was an effective strategy to improve solubility and dissolution of poor soluble IBR.
Journal ArticleDOI
Amorphous Pharmaceutical Solids: Preparation, Characterization and Stabilization
TL;DR: The importance of amorphous pharmaceutical solids lies in their useful properties, common occurrence, and physicochemical instability relative to corresponding crystals as mentioned in this paper, and their properties reveal their structures, thermodynamic properties, and changes (crystallization and structural relaxation) in single and multi-component systems.
Journal ArticleDOI
Characterization, quantification and stability of differently prepared amorphous forms of some oral hypoglycaemic agents
TL;DR: Analysis showed that amorphous form of repaglinide prepared by quench cooling is most stable and has the potential to be formulated without any additive while amorphously form of gliclazide tends to devitrify pointing towards its unstable nature.
Journal ArticleDOI
Smart reticulated hydrogel of functionally decorated gellan copolymer for prolonged delivery of salbutamol sulphate to the gastro-luminal milieu
TL;DR: Differential scanning calorimetry, X-ray diffraction, and high-performance liquid chromatography analyses confirmed the amorphous nature of the drug and its stability in fresh and aged hydrogel and had the potential to prolong drug release mimicking the variable pH of the gastrointestinal tract.
Journal ArticleDOI
Surface Diffusion Is Controlled by Bulk Fragility across All Glass Types.
Yuhui Li,Ajay Annamareddy,Dane Morgan,Zheng Yu,Bu Wang,Chengrong Cao,John H. Perepezko,Mark Ediger,Paul M. Voyles,Liandong Yu +9 more
TL;DR: This article showed that surface diffusion is significantly faster than bulk diffusion in some glasses, but only moderately enhanced in others, and that this variation is closely linked to bulk fragility, a measure of how quickly dynamics is excited when a glass is heated to become a liquid.
References
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On the Temperature Dependence of Cooperative Relaxation Properties in Glass‐Forming Liquids
Gerold Adam,Julian H. Gibbs +1 more
TL;DR: In this paper, a molecularkinetic theory was proposed to explain the temperature dependence of relaxation behavior in glass-forming liquids in terms of the temperature variation of the size of the cooperatively rearranging region.
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The theory of transformations in metals and alloys : an advanced textbook in physical metallurgy
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Formation of glasses from liquids and biopolymers.
TL;DR: The onset of a sharp change in ddT( is the Debye-Waller factor and T is temperature) in proteins, which is controversially indentified with the glass transition in liquids, is shown to be general for glass formers and observable in computer simulations of strong and fragile ionic liquids, where it proves to be close to the experimental glass transition temperature.
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The theory of transformations in metals and alloys
J.W. Christian,H. M. Otte +1 more
TL;DR: In this paper, the authors present a general introduction to the theory of transformation kinetics of real metals, including the formation and evolution of martensitic transformations, as well as a theory of dislocations.
Journal ArticleDOI
Nonexponential relaxations in strong and fragile glass formers
TL;DR: In this article, a broad correlation of non-debye behavior with non-Arrhenius relaxations was found for different types of glass formers, distinguished by their respective molecular complexity.
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