Journal ArticleDOI
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
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TLDR
Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2001-05-16. It has received 1367 citations till now. The article focuses on the topics: Amorphous solid & Crystallization.read more
Citations
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Journal ArticleDOI
Pharmaceutical particle engineering via spray drying.
TL;DR: A classification based on dimensionless numbers is presented that can be used to estimate how excipient properties in combination with process parameters influence the morphology of the engineered particles.
Journal ArticleDOI
Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates.
TL;DR: The concept and theory of crystal engineering is covered and the potential benefits, disadvantages and methods of preparation of co-crystals, metastable polymorphs, high-energy amorphous forms and ultrafine particles are discussed.
Journal ArticleDOI
Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Journal ArticleDOI
Insoluble drug delivery strategies: review of recent advances and business prospects
TL;DR: A review of the recent advances in the field of insoluble drug delivery and business prospects covers the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility.
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Solubility Advantage of Amorphous Drugs and Pharmaceutical Cocrystals
N. Jagadeesh Babu,Ashwini Nangia +1 more
TL;DR: In this article, the authors reviewed several novel examples of pharmaceutical cocrystals from the past decade and analyzed the enhanced solubility profiles of cocrystal profiles, showing that the peak dissolution for pharmaceutical cocystals occurs in a short time (<30 min), and high-solubility is maintained over a sufficiently long period (4-6 h) for the best cases.
References
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Journal Article
The stability of cyclophosphamide in lyophilized cakes. Part I. Mannitol, lactose, and sodium bicarbonate as excipients.
Kovalcik Tr,Guillory Jk +1 more
TL;DR: In the cakes containing mannitol or sodium bicarbonate as adjuvants, differential scanning calorimetry and X-ray diffraction showed that cyclophosphamide was converted from the amorphous to the monohydrate form when exposed to moisture, and exhibited improved stability.
Journal ArticleDOI
Determination of enthalpy relaxation times using traditional differential scanning calorimetry for glycerol and for propylene glycol
TL;DR: In this article, the isothermal enthalpy relaxation of glycerol and propylene glycol is studied for different subglass transition annealing temperatures using our usual method using the Kohlrausch-Williams-Watts model.
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Crystalline Modifications of D-Mannitol.
Journal ArticleDOI
Thermal analysis of amorphous phase in a pharmaceutical drug
TL;DR: In this paper, TSC spectroscopy and DSC were applied to the characterization of the microstructure of a pharmaceutical drug and the results showed that TSC was more accurate than DSC.
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