Journal ArticleDOI
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
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TLDR
Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2001-05-16. It has received 1367 citations till now. The article focuses on the topics: Amorphous solid & Crystallization.read more
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Macrocyclic modulators of the ghrelin receptor
TL;DR: In this paper, a conformationally defined macrocyclic compound that has been demonstrated to be a selective modulator of the ghrelin receptor (GHS-R1a and subtypes, isoforms and variants thereof) is described.
Journal ArticleDOI
Structural relaxation of vapor-deposited molecular glasses and supercooled liquids
Kikujiro Ishii,Hideyuki Nakayama +1 more
TL;DR: The research history of vapor-deposited molecular glasses, the concepts of amorphous solid and glass, and the methods for studying molecular glasses are summarized; the research results reported to date for molecular glasses and related supercooled liquids are summarized.
Journal ArticleDOI
Amorphous solid dispersion method for improving oral bioavailability of poorly water-soluble drugs
TL;DR: Amorphous solid dispersions are one of the most promising strategies to improve the oral bioavailability of sparingly water-soluble drugs as discussed by the authors, and they have been shown to improve drug wettability and bioavailability significantly.
Journal ArticleDOI
Facile formation of co-amorphous atenolol and hydrochlorothiazide mixtures via cryogenic-milling: Enhanced physical stability, dissolution and pharmacokinetic profile.
TL;DR: The present study provides an improved approach to implement the combination therapy of ATE and HCT for potential clinical treatments and found that the enhanced bioavailability of HCT in the co-amorphous formulation was achieved by the synergistic effect of amorphized HCT and the water-soluble coformer ATE.
Journal ArticleDOI
Confined crystallization of fenofibrate in nanoporous silica
TL;DR: Nanocrystalline fenofibrate was formed in pore sizes greater than 20 nm and showed characteristic melting point depressions following a Gibbs-Thomson relationship as well as enhanced dissolution rates, which help to advance the fundamental understanding of nanocrystallization in confined pores.
References
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Journal ArticleDOI
On the Temperature Dependence of Cooperative Relaxation Properties in Glass‐Forming Liquids
Gerold Adam,Julian H. Gibbs +1 more
TL;DR: In this paper, a molecularkinetic theory was proposed to explain the temperature dependence of relaxation behavior in glass-forming liquids in terms of the temperature variation of the size of the cooperatively rearranging region.
Book
The theory of transformations in metals and alloys : an advanced textbook in physical metallurgy
Journal ArticleDOI
Formation of glasses from liquids and biopolymers.
TL;DR: The onset of a sharp change in ddT( is the Debye-Waller factor and T is temperature) in proteins, which is controversially indentified with the glass transition in liquids, is shown to be general for glass formers and observable in computer simulations of strong and fragile ionic liquids, where it proves to be close to the experimental glass transition temperature.
Book
The theory of transformations in metals and alloys
J.W. Christian,H. M. Otte +1 more
TL;DR: In this paper, the authors present a general introduction to the theory of transformation kinetics of real metals, including the formation and evolution of martensitic transformations, as well as a theory of dislocations.
Journal ArticleDOI
Nonexponential relaxations in strong and fragile glass formers
TL;DR: In this article, a broad correlation of non-debye behavior with non-Arrhenius relaxations was found for different types of glass formers, distinguished by their respective molecular complexity.
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