Journal ArticleDOI
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
Reads0
Chats0
TLDR
Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2001-05-16. It has received 1367 citations till now. The article focuses on the topics: Amorphous solid & Crystallization.read more
Citations
More filters
Journal ArticleDOI
Solid-State and Particle Size Control of Pharmaceutical Cocrystals using Atomization-Based Techniques.
TL;DR: In this paper , the benefits of employing atomization-based methods for the generation of pharmaceutical cocrystals, examines the most recent regulatory changes regarding cocrystal and provides an outlook towards the future of this field.
Journal ArticleDOI
Effects of light on metalloporphyrin-treated newborn mice.
Ronald J. Wong,Stephanie Schulz,Cecilia Espadas,Hendrik J. Vreman,Jayakumar Rajadas,David K. Stevenson +5 more
TL;DR: Intragastric administration of ZnPP microparticles to 3‐day‐old mice resulted in a twofold increase in potency and no signs of phototoxicity.
Journal ArticleDOI
Quantitative Macro-Raman Spectroscopy on Microparticle-Based Pharmaceutical Dosage Forms.
TL;DR: To quantify the error caused by sample heterogeneity, a Monte Carlo model was developed to predict the minimum sample volume required for representative sampling of potentially heterogeneous samples at the microscopic level, characterized by different particle-size distributions and compositions.
Patent
Sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
TL;DR: A preparation replete with crystals of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection as discussed by the authors.
Journal ArticleDOI
Production of Copaiba oleoresin particles from emulsions stabilized with modified starches
José Luis Pasquel Reátegui,Francisco Manuel Barrales,Camila A. Rezende,Carmen L. Queiroga,Julian Martínez +4 more
TL;DR: In this paper, copaiba oleoresin was encapsulated within polymeric particles through emulsification assisted by ultrasound followed by a drying process, which led to the formation of kinetically stable emulsions.
References
More filters
Journal ArticleDOI
On the Temperature Dependence of Cooperative Relaxation Properties in Glass‐Forming Liquids
Gerold Adam,Julian H. Gibbs +1 more
TL;DR: In this paper, a molecularkinetic theory was proposed to explain the temperature dependence of relaxation behavior in glass-forming liquids in terms of the temperature variation of the size of the cooperatively rearranging region.
Book
The theory of transformations in metals and alloys : an advanced textbook in physical metallurgy
Journal ArticleDOI
Formation of glasses from liquids and biopolymers.
TL;DR: The onset of a sharp change in ddT( is the Debye-Waller factor and T is temperature) in proteins, which is controversially indentified with the glass transition in liquids, is shown to be general for glass formers and observable in computer simulations of strong and fragile ionic liquids, where it proves to be close to the experimental glass transition temperature.
Book
The theory of transformations in metals and alloys
J.W. Christian,H. M. Otte +1 more
TL;DR: In this paper, the authors present a general introduction to the theory of transformation kinetics of real metals, including the formation and evolution of martensitic transformations, as well as a theory of dislocations.
Journal ArticleDOI
Nonexponential relaxations in strong and fragile glass formers
TL;DR: In this article, a broad correlation of non-debye behavior with non-Arrhenius relaxations was found for different types of glass formers, distinguished by their respective molecular complexity.
Related Papers (5)
Characteristics and Significance of the Amorphous State in Pharmaceutical Systems
Bruno C. Hancock,George Zografi +1 more
What is the true solubility advantage for amorphous pharmaceuticals
Bruno C. Hancock,Michael Parks +1 more