Journal ArticleDOI
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
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TLDR
Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2001-05-16. It has received 1367 citations till now. The article focuses on the topics: Amorphous solid & Crystallization.read more
Citations
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Effects of heating conditions on the glass transition parameters of amorphous sucrose produced by melt-quenching.
TL;DR: It is shown that, depending on the heating conditions employed, a different amount and variety of sucrose thermal decomposition components may be formed, giving rise to wide variation in the amorphous sucrose T(g) values.
Journal ArticleDOI
Finding the Needle in the Haystack: Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy.
TL;DR: Second harmonic generation (SHG) microscopy was used to rapidly identify regions of interest for localized confocal Raman spectroscopy measurements in order to quantify crystallinity within lyophilized Abraxane powder, consistent with up to 30% of the active ingredient being present as poorly soluble crystalline particulates in some batches of Abraxan.
Journal ArticleDOI
Construction and Validation of Binary Phase Diagram for Amorphous Solid Dispersion Using Flory–Huggins Theory
TL;DR: The results suggest possibility of employing interaction parameter as preliminary tool for the estimation of drug–polymer miscibility and solubility on the basis of Flory–Huggins (F–H) theory and experimental validation of the phase diagram.
Journal ArticleDOI
Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release.
Francesco Tres,Kevin Treacher,Jonathan Booth,Leslie P. Hughes,Stephen A.C. Wren,Jonathan W. Aylott,Jonathan C. Burley +6 more
TL;DR: It is found that in pH 2 HCl buffer, for the 15% or higher drug-loaded extrudates, Kollidon VA64 preferentially dissolves from the exterior of the compact leaving an amorphous drug-rich hydrophobic shell, which, similarly to an enteric coating, inhibits the drug release.
Journal ArticleDOI
Amorphization of a crystalline active pharmaceutical ingredient and thermoanalytical measurements on this glassy form
TL;DR: In this paper, the amorphization of clopidogrel hydrogen sulphate as an active pharmaceutical ingredient (API) with various solvents and to determine the glass-transition temperature (Tg) of this API was determined.
References
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On the Temperature Dependence of Cooperative Relaxation Properties in Glass‐Forming Liquids
Gerold Adam,Julian H. Gibbs +1 more
TL;DR: In this paper, a molecularkinetic theory was proposed to explain the temperature dependence of relaxation behavior in glass-forming liquids in terms of the temperature variation of the size of the cooperatively rearranging region.
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The theory of transformations in metals and alloys : an advanced textbook in physical metallurgy
Journal ArticleDOI
Formation of glasses from liquids and biopolymers.
TL;DR: The onset of a sharp change in ddT( is the Debye-Waller factor and T is temperature) in proteins, which is controversially indentified with the glass transition in liquids, is shown to be general for glass formers and observable in computer simulations of strong and fragile ionic liquids, where it proves to be close to the experimental glass transition temperature.
Book
The theory of transformations in metals and alloys
J.W. Christian,H. M. Otte +1 more
TL;DR: In this paper, the authors present a general introduction to the theory of transformation kinetics of real metals, including the formation and evolution of martensitic transformations, as well as a theory of dislocations.
Journal ArticleDOI
Nonexponential relaxations in strong and fragile glass formers
TL;DR: In this article, a broad correlation of non-debye behavior with non-Arrhenius relaxations was found for different types of glass formers, distinguished by their respective molecular complexity.
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