Journal ArticleDOI
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
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TLDR
Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2001-05-16. It has received 1367 citations till now. The article focuses on the topics: Amorphous solid & Crystallization.read more
Citations
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Stable Glasses of Organic Semiconductor Resist Crystallization
TL;DR: In this article, the authors showed that PVD glasses can also show enhanced resistance to crystallization by controlling the deposition temperature of the PVD glass, which can increase the glass → liquid transformation time thereby increasing the overall time for crystallization.
Journal ArticleDOI
Preparation of drug polymorphs (a review)
D. T. Guranda,G. N. Gil’deeva +1 more
TL;DR: In this article, the most effective methods used to obtain polymorphous modifications of drug substances are based on crystallization, which is governed by both thermodynamic and kinetic factors; therefore, the preparation of certain drug polymorphs requires strict control of the crystallization conditions.
Development of multivariate powder X-ray diffraction techniques and total scattering analyses to enable informatic calibration of solid dispersion potential
TL;DR: In this paper, the development of MULTIVARIATE POWDER X-ray DIF-FACTION TECHNIQUES and total scattering ANALYSES to ENABLE INFORMATIC CALIBRATION of SOLID DISPERSION is discussed.
Patent
Amorphous lercanidipine hydrochloride
TL;DR: A substantially pure amorphous lercanidipine hydrochloride with a purity of at least 95 % pure, preferably at least about 97% pure, more than 99% pure and still more than about 99.5 % pure was proposed in this paper.
Journal ArticleDOI
Theoretical and experimental validation of praziquantel with different polymers for selection of an appropriate matrix for hot-melt extrusion.
TL;DR: In this paper, the authors evaluated the possibility of three different polymers, namely, Eudragit®EPO, polyvinyl alcohol (PVA), Kollicoat®IR (KIR) with Praziquantel (PZQ), with proper validation of the Flory-Huggins theory and construction of the phase diagram using the melting point depression approach to determine a suitable matrix for HME.
References
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On the Temperature Dependence of Cooperative Relaxation Properties in Glass‐Forming Liquids
Gerold Adam,Julian H. Gibbs +1 more
TL;DR: In this paper, a molecularkinetic theory was proposed to explain the temperature dependence of relaxation behavior in glass-forming liquids in terms of the temperature variation of the size of the cooperatively rearranging region.
Book
The theory of transformations in metals and alloys : an advanced textbook in physical metallurgy
Journal ArticleDOI
Formation of glasses from liquids and biopolymers.
TL;DR: The onset of a sharp change in ddT( is the Debye-Waller factor and T is temperature) in proteins, which is controversially indentified with the glass transition in liquids, is shown to be general for glass formers and observable in computer simulations of strong and fragile ionic liquids, where it proves to be close to the experimental glass transition temperature.
Book
The theory of transformations in metals and alloys
J.W. Christian,H. M. Otte +1 more
TL;DR: In this paper, the authors present a general introduction to the theory of transformation kinetics of real metals, including the formation and evolution of martensitic transformations, as well as a theory of dislocations.
Journal ArticleDOI
Nonexponential relaxations in strong and fragile glass formers
TL;DR: In this article, a broad correlation of non-debye behavior with non-Arrhenius relaxations was found for different types of glass formers, distinguished by their respective molecular complexity.
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