Journal ArticleDOI
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
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TLDR
Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2001-05-16. It has received 1367 citations till now. The article focuses on the topics: Amorphous solid & Crystallization.read more
Citations
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Study on the glass transition dynamics and crystallization kinetics of molecular liquid, dimethyl phthalate, confined in Anodized Aluminum Oxide (AAO) nanopores with Atomic Layer Deposition (ALD) coatings
TL;DR: In this article, the effect of surface modification on the glassy dynamics and crystallization tendency of van der Waals liquid embedded within cylindrical nanopores was examined using dielectric spectroscopy (DS) and differential scanning calcorimetry (DSC).
Journal ArticleDOI
Modeling Recrystallization Kinetics Following the Dissolution of Amorphous Drugs
TL;DR: Two semi-empirical models, based on dispersive kinetics theory, are evaluated for their ability to precisely describe experimental transients depicting a loss in supersaturation (initially generated by the dissolution of the amorphous phase) over time, as the solubilized drug recrystallizes.
Dissertation
The development of PVP-based solid dispersions using hot melt extrusion for the preparation of immediate release formulations
TL;DR: In this article, the feasibility of using polyvinylpyrrolidone (PVP) and its derivative in HME manufacturing method was explored. But, the use of PVP is limited due to the concerns of its physical instability, unpredictability and inconsistency formulation performance.
Journal ArticleDOI
Effect of heating rate and kinetic model selection on activation energy of nonisothermal crystallization of amorphous felodipine.
TL;DR: This work systematically evaluates how the model-dependent crystallization kinetics is impacted by variations in the heating rate and the selection of the kinetic model, two key factors that can lead to significant differences in the crystallization activation energy (Ea) of an amorphous material.
References
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Journal ArticleDOI
On the Temperature Dependence of Cooperative Relaxation Properties in Glass‐Forming Liquids
Gerold Adam,Julian H. Gibbs +1 more
TL;DR: In this paper, a molecularkinetic theory was proposed to explain the temperature dependence of relaxation behavior in glass-forming liquids in terms of the temperature variation of the size of the cooperatively rearranging region.
Book
The theory of transformations in metals and alloys : an advanced textbook in physical metallurgy
Journal ArticleDOI
Formation of glasses from liquids and biopolymers.
TL;DR: The onset of a sharp change in ddT( is the Debye-Waller factor and T is temperature) in proteins, which is controversially indentified with the glass transition in liquids, is shown to be general for glass formers and observable in computer simulations of strong and fragile ionic liquids, where it proves to be close to the experimental glass transition temperature.
Book
The theory of transformations in metals and alloys
J.W. Christian,H. M. Otte +1 more
TL;DR: In this paper, the authors present a general introduction to the theory of transformation kinetics of real metals, including the formation and evolution of martensitic transformations, as well as a theory of dislocations.
Journal ArticleDOI
Nonexponential relaxations in strong and fragile glass formers
TL;DR: In this article, a broad correlation of non-debye behavior with non-Arrhenius relaxations was found for different types of glass formers, distinguished by their respective molecular complexity.
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