Journal ArticleDOI
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
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TLDR
Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2001-05-16. It has received 1367 citations till now. The article focuses on the topics: Amorphous solid & Crystallization.read more
Citations
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Pharmaceutical particle engineering via spray drying.
TL;DR: A classification based on dimensionless numbers is presented that can be used to estimate how excipient properties in combination with process parameters influence the morphology of the engineered particles.
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Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates.
TL;DR: The concept and theory of crystal engineering is covered and the potential benefits, disadvantages and methods of preparation of co-crystals, metastable polymorphs, high-energy amorphous forms and ultrafine particles are discussed.
Journal ArticleDOI
Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
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Insoluble drug delivery strategies: review of recent advances and business prospects
TL;DR: A review of the recent advances in the field of insoluble drug delivery and business prospects covers the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility.
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Solubility Advantage of Amorphous Drugs and Pharmaceutical Cocrystals
N. Jagadeesh Babu,Ashwini Nangia +1 more
TL;DR: In this article, the authors reviewed several novel examples of pharmaceutical cocrystals from the past decade and analyzed the enhanced solubility profiles of cocrystal profiles, showing that the peak dissolution for pharmaceutical cocystals occurs in a short time (<30 min), and high-solubility is maintained over a sufficiently long period (4-6 h) for the best cases.
References
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Journal ArticleDOI
One- and two-step calorimetric studies of crystallization kinetics in simple ionic glass-forming liquids. 1. Calcium nitrate-potassium nitrate system
TL;DR: Isothermal calorimetric studies of crystal nucleation and growth processes in the aqueous LiCl-H{sub 2}O have been carried out in this paper, where the results obtained by using emulsion samples, which protect against heterogeneous nucleation artifacts, can be reproduced by using bulk samples.
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Temperature calibration on cooling using liquid crystal phase transitions
TL;DR: In this paper, the A to nematic transition of biphenyles fulfils the conditions required for verifying the symmetry of the temperature calibration in heating and cooling modes at at least one temperature.
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Transport phenomena and anomalous glass-forming behaviour in alpha , alpha-trehalose aqueous solutions
TL;DR: In this article, the transport properties of aqueous solutions of the three disaccharides sucrose, maltose and trehalose are investigated by viscosity and NMR measurements.
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Accurate temperature calibration of differential scanning calorimeters
Peter Skoglund,Åke Fransson +1 more
TL;DR: In this paper, power-compensated differential scanning calorimeters are used in measurements on cooling, and the authors discuss and present new results on different methods for calibration for cooling.
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Towards understanding 13C-N.M.R. chemical shifts of carbohydrates in the solid state. The spectra of d-mannitol polymorphs and of dl-mannitol
TL;DR: The cross-polarization, magic-angle spinning 13 C-n.m.r. spectra of solid dl -mannitol and three polymorphs of d-mannitol have been recorded and assigned as mentioned in this paper.
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