AMPARs and Synaptic Plasticity: The Last 25 Years
TLDR
The progress over the last two and a half decades is reviewed, the future challenges in the field are discussed and a large number of proteins have been identified that regulate this complex process.About:
This article is published in Neuron.The article was published on 2013-10-30 and is currently open access. It has received 783 citations till now. The article focuses on the topics: Metaplasticity & Synaptic scaling.read more
Citations
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Journal ArticleDOI
A Brief History of Long-Term Potentiation.
TL;DR: The rich history of LTP is reviewed, which provides a compelling cellular model for learning and memory and shows how the pace of discovery is remarkable.
Journal ArticleDOI
Hippocampal GABAergic Inhibitory Interneurons.
Kenneth A. Pelkey,Ramesh Chittajallu,Michael T. Craig,Ludovic Tricoire,Ludovic Tricoire,Jason C. Wester,Jason C. Wester,Chris J. McBain,Chris J. McBain +8 more
TL;DR: An overview of the current state of the field of interneuron research, focusing largely on the hippocampus, discusses recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations.
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The AMPA Receptor Code of Synaptic Plasticity.
TL;DR: The AMPAR code suggests that AMPAR variants will be predictive of the types and extent of synaptic plasticity that can occur and that a hierarchy exists such that certain AMPARs will be disproportionally recruited to synapses during LTP/homeostatic scaling up, or removed during LTD/homeOSTatic scaling down.
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Ultrastructural evidence for synaptic scaling across the wake/sleep cycle.
Luisa de Vivo,Michele Bellesi,Michele Bellesi,William Marshall,Eric A. Bushong,Mark H. Ellisman,Giulio Tononi,Chiara Cirelli +7 more
TL;DR: The hypothesis that a core function of sleep is to renormalize overall synaptic strength increased by wake is supported, as measured in mouse motor and sensory cortices.
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Homer1a drives homeostatic scaling-down of excitatory synapses during sleep
Graham H. Diering,Raja Sekhar Nirujogi,Richard H. Roth,Paul F. Worley,Akhilesh Pandey,Richard L. Huganir +5 more
TL;DR: Using biochemistry, proteomics, and imaging in mice, it is found that during sleep, synapses undergo widespread alterations in composition and signaling, including weakening of synapses through removal and dephosphorylation of synaptic AMPA-type glutamate receptors.
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