Journal ArticleDOI
An analysis of rat prefrontal cortex in mediating executive function.
TLDR
The data suggest that there is subregional specificity within the PFC of rats, monkey and humans and there are parallel cognitive functions of the different subregions of the P FC in rats, monkeys and humans.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2011-10-01. It has received 342 citations till now. The article focuses on the topics: Working memory & Executive functions.read more
Citations
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Book ChapterDOI
Prefrontal Cortex and Basal Ganglia Attributes Underlying Behavioral Flexibility
TL;DR: The chapter describes recent findings indicating that the prelimbic cortex along with the subthalamic nucleus and dorsomedial striatum acts in a cooperative manner to enable behavioral flexibility when cues, as opposed to outcomes, guide a proactive behavioral switch.
Book ChapterDOI
Frontal Lobe Dysfunction After Developmental Alcohol Exposure: Implications From Animal Models
TL;DR: Rodent models corroborate these findings, contributing mechanistic approaches to frontal lobe damage on cellular and subcellular levels following alcohol exposure during periods developmentally analogous to human gestation as mentioned in this paper.
Journal ArticleDOI
Food reward induction of rhythmic clock gene expression in the prefrontal cortex of rats is accompanied by changes in miR-34a-5p expression
TL;DR: In this paper, the authors focused on mechanisms by which the peripheral circadian oscillator in the prefrontal cortex (PFC) participates in food reward-induced activity and found that when synchronisation to a new light:dark cycle was accompanied by intake of food reward, animals exerted more exact phase shift compared to the controls.
Journal ArticleDOI
Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D1 Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms
TL;DR: D1-related dose-dependent regulation of working memory can be modified differentially by functionally selective ligands, theoretically increasing the balance between desired and undesired effects.
References
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Journal ArticleDOI
An integrative theory of prefrontal cortex function
Earl K. Miller,Jonathan D. Cohen +1 more
TL;DR: It is proposed that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them, which provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task.
Journal ArticleDOI
Insensitivity to future consequences following damage to human prefrontal cortex
TL;DR: Using a novel task which simulates real-life decision-making in the way it factors uncertainty of premises and outcomes, as well as reward and punishment, it is found that prefrontal patients are oblivious to the future consequences of their actions, and seem to be guided by immediate prospects only.
Book
The Cognitive Neurosciences
TL;DR: The fourth edition of The Cognitive Neurosciences continues to chart new directions in the study of the biologic underpinnings of complex cognition -the relationship between the structural and physiological mechanisms of the nervous system and the psychological reality of the mind as discussed by the authors.
Journal ArticleDOI
Specific impairments of planning
TL;DR: An information-processing model is outlined that predicts that performance on non-routine tasks can be impaired independently of performance on routine tasks, related to views on frontal lobe functions, particularly those of Luria.
Journal ArticleDOI
Separate Neural Systems Value Immediate and Delayed Monetary Rewards
TL;DR: The authors examined the neural correlates of time discounting while subjects made a series of choices between monetary reward options that varied by delay to delivery and demonstrated that two separate systems are involved in such decisions.