Journal ArticleDOI
An analysis of rat prefrontal cortex in mediating executive function.
TLDR
The data suggest that there is subregional specificity within the PFC of rats, monkey and humans and there are parallel cognitive functions of the different subregions of the P FC in rats, monkeys and humans.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2011-10-01. It has received 342 citations till now. The article focuses on the topics: Working memory & Executive functions.read more
Citations
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The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
Bruce S. McEwen,John H. Morrison +1 more
TL;DR: The prefrontal cortex is involved in working memory and self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued.
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The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear.
Thomas F. Giustino,Stephen Maren +1 more
TL;DR: A division of labor has been proposed in which the prelimbic (PL) and infralimbic (IL) subdivisions of the medial prefrontal cortex (mPFC) regulate the expression and suppression of fear in rodents, respectively.
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A Review of the Pathophysiology, Etiology, and Treatment of Attention-Deficit Hyperactivity Disorder (ADHD)
Alok Sharma,Justin Couture +1 more
TL;DR: This review focuses on the pathophysiology, etiology, and treatment of ADHD and details the adverse effects and drug interaction profiles of the drugs used to treat it.
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The hippocampal-prefrontal pathway: The weak link in psychiatric disorders?
TL;DR: The H-PFC pathway is a potentially crucial element of the pathophysiology of several psychiatric diseases, and it offers a specific target for therapeutic intervention, which is consistent with the recent emphasis on reframing psychiatric diseases in terms of brain circuits.
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The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition
Sheree F. Logue,Thomas J. Gould +1 more
TL;DR: This review will examine the influence of dopamine, norepinephrine, serotonin, and acetylcholine on the following measures of executive function: attention, cognitive flexibility, and impulse control and the effects of polymorphisms in genes associated with these neurotransmitter systems on these measures.
References
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Neuronal connections of orbital cortex in rats: topography of cortical and thalamic afferents.
TL;DR: In this article, the cortical and thalamic afferent connections of rat orbital cortex were investigated using fluorescent retrograde axonal tracers, and the connections of the ventral and ventrolateral orbital areas were interpreted in the context of directed attention and allocentric spatial localization.
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Septohippocampal system and the prelimbic sector of frontal cortex: a neuropsychological battery analysis in the rat
TL;DR: Rats with septal (SEP) lesions spent more time eating than control (CON) rats and rats with lesions in prelimbic cortex (PRE) and showed improvement with continued practice at brief intertrial and interrun intervals.
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Visuo-motor conditional associative learning after frontal and temporal lesions in the human brain.
TL;DR: Patients with unilateral frontal- or temporal-lobe excisions were tested on a visuo-motor conditional associative task with a modified procedure and were severely impaired in learning this task.
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Prefrontal unit activity during delayed conditional Go/No-Go discrimination in the monkey. II. Relation to Go and No-Go responses.
TL;DR: The existence of the 3 types of prefrontal units (Go, No-go and Go/No-go) indicates that the prefrontal cortex is involved in the Behavioral inhibitory mechanism besides participating in the behavioral excitatory mechanism.
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Dissociation of item and order spatial memory in rats following medial prefrontal cortex lesions
TL;DR: The data suggest that the medial prefrontal cortex is involved in temporal structuring of information, and in general, the data suggest a partial, but not complete, dissociation of item-order memory.