Journal ArticleDOI
An analysis of rat prefrontal cortex in mediating executive function.
TLDR
The data suggest that there is subregional specificity within the PFC of rats, monkey and humans and there are parallel cognitive functions of the different subregions of the P FC in rats, monkeys and humans.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2011-10-01. It has received 342 citations till now. The article focuses on the topics: Working memory & Executive functions.read more
Citations
More filters
Journal ArticleDOI
Unfolding the cognitive map: The role of hippocampal and extra-hippocampal substrates based on a systems analysis of spatial processing.
TL;DR: This review will describe spatial memory in terms of a system model incorporating partially overlapping and interacting event‐based, knowledge‐based and rule‐based memory systems that are composed of different component processes or attributes associated with spatial processing which are mapped onto the corresponding neural substrates and larger networks.
Journal ArticleDOI
Modeling deficits in attention, inhibition, and flexibility in HAND.
TL;DR: The functional consequences of chronic low-level expression of the HIV-1 proteins on attention, as well as inhibition and flexibility as core components of executive function, are apparent under conditions which resemble the brain proinflammatory immune responses and suppression of infection in HIV- 1+ individuals under cART.
Journal ArticleDOI
The impact of cafeteria diet feeding on physiology and anxiety-related behaviour in male and female Sprague-Dawley rats of different ages
TL;DR: It is demonstrated that feeding CD leads to both obesity and behavioural changes in rats, with the behavioural effects being particularly gender dependent in older rats.
Journal ArticleDOI
Effects of acute or chronic environmental enrichment on regional Fos protein expression following sucrose cue-reactivity testing in rats
Jeffrey W. Grimm,Jesse L. Barnes,Jesse L. Barnes,Jonathon Koerber,Jonathon Koerber,Edwin Glueck,Darren Ginder,Jeff Hyde,Laura Eaton +8 more
TL;DR: In this article, the authors examined whether exposure to environmental enrichment (EE) reduces sucrose seeking by rats with a history of self-administration and whether acute or chronic EE also reduces brain Fos levels, a protein marker indicative of neuronal activation.
Journal ArticleDOI
Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions
Amanda N. Carey,Xiaoxu Liu,Dionyssios Mintzopoulos,Jason J. Paris,John W. Muschamp,Jay P. McLaughlin,Jay P. McLaughlin,Marc J. Kaufman +7 more
TL;DR: These experiments provide the first neuroimaging evidence that conditional Tat protein expression in the GT-tg bigenic mouse model alters brain structure, and warrant future studies to further characterize effects of conditional Tat expression on brain structure.
References
More filters
Journal ArticleDOI
An integrative theory of prefrontal cortex function
Earl K. Miller,Jonathan D. Cohen +1 more
TL;DR: It is proposed that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them, which provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task.
Journal ArticleDOI
Insensitivity to future consequences following damage to human prefrontal cortex
TL;DR: Using a novel task which simulates real-life decision-making in the way it factors uncertainty of premises and outcomes, as well as reward and punishment, it is found that prefrontal patients are oblivious to the future consequences of their actions, and seem to be guided by immediate prospects only.
Book
The Cognitive Neurosciences
TL;DR: The fourth edition of The Cognitive Neurosciences continues to chart new directions in the study of the biologic underpinnings of complex cognition -the relationship between the structural and physiological mechanisms of the nervous system and the psychological reality of the mind as discussed by the authors.
Journal ArticleDOI
Specific impairments of planning
TL;DR: An information-processing model is outlined that predicts that performance on non-routine tasks can be impaired independently of performance on routine tasks, related to views on frontal lobe functions, particularly those of Luria.
Journal ArticleDOI
Separate Neural Systems Value Immediate and Delayed Monetary Rewards
TL;DR: The authors examined the neural correlates of time discounting while subjects made a series of choices between monetary reward options that varied by delay to delivery and demonstrated that two separate systems are involved in such decisions.