Journal ArticleDOI
An analysis of rat prefrontal cortex in mediating executive function.
TLDR
The data suggest that there is subregional specificity within the PFC of rats, monkey and humans and there are parallel cognitive functions of the different subregions of the P FC in rats, monkeys and humans.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2011-10-01. It has received 342 citations till now. The article focuses on the topics: Working memory & Executive functions.read more
Citations
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Journal ArticleDOI
The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
Bruce S. McEwen,John H. Morrison +1 more
TL;DR: The prefrontal cortex is involved in working memory and self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued.
Journal ArticleDOI
The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear.
Thomas F. Giustino,Stephen Maren +1 more
TL;DR: A division of labor has been proposed in which the prelimbic (PL) and infralimbic (IL) subdivisions of the medial prefrontal cortex (mPFC) regulate the expression and suppression of fear in rodents, respectively.
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A Review of the Pathophysiology, Etiology, and Treatment of Attention-Deficit Hyperactivity Disorder (ADHD)
Alok Sharma,Justin Couture +1 more
TL;DR: This review focuses on the pathophysiology, etiology, and treatment of ADHD and details the adverse effects and drug interaction profiles of the drugs used to treat it.
Journal ArticleDOI
The hippocampal-prefrontal pathway: The weak link in psychiatric disorders?
TL;DR: The H-PFC pathway is a potentially crucial element of the pathophysiology of several psychiatric diseases, and it offers a specific target for therapeutic intervention, which is consistent with the recent emphasis on reframing psychiatric diseases in terms of brain circuits.
Journal ArticleDOI
The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition
Sheree F. Logue,Thomas J. Gould +1 more
TL;DR: This review will examine the influence of dopamine, norepinephrine, serotonin, and acetylcholine on the following measures of executive function: attention, cognitive flexibility, and impulse control and the effects of polymorphisms in genes associated with these neurotransmitter systems on these measures.
References
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Book ChapterDOI
The prefrontal cortex and the integration of sensory, limbic and autonomic information.
TL;DR: An overview of the afferent and efferent connections of the prefrontal cortex (PFC) in primates and rats is discussed, and in the light of this circuitry, the presumptive functional role of the PFC in integrating sensory, motor, cognitive, emotional and autonomic functions is discussed.
Journal ArticleDOI
A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats
TL;DR: The results suggest that the frontal andParietal cortex of rats play different roles in the control of spatial orientation but do not support the view that egocentric and allocentric spatial orientation are related to frontal and parietal mechanisms, respectively.
Journal ArticleDOI
Prospective Coding for Objects in Primate Prefrontal Cortex
TL;DR: Examination of neural activity in prefrontal (PF) cortex of monkeys performing a delayed paired associate task provides further confirmation that PF cortex does not simply buffer incoming visual inputs, but instead selectively processes information relevant to current behavioral demands, even when this information must be recalled from long-term memory.
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Deficits on conditional associative-learning tasks after frontal- and temporal-lobe lesions in man
TL;DR: Patients with unilateral frontal- or temporal-lobe excisions were tested on a spatial and a nonspatial conditional associative task and those with more radical involvement of the hippocampal region exhibited deficits that were material-specific and varied with the side of the lesion.
Journal ArticleDOI
Separate Valuation Subsystems for Delay and Effort Decision Costs
Charlotte Prévost,Mathias Pessiglione,Elise Météreau,Marie-Laure Cléry-Melin,Jean-Claude Dreher +4 more
TL;DR: It is shown that humans devalue rewards associated with physical effort in a strikingly similar fashion to those they devalue that are associated with delays, and that a single computational model derived from economics theory can account for the behavior observed in both delay discounting and effort discounting.