Journal ArticleDOI
An analysis of rat prefrontal cortex in mediating executive function.
TLDR
The data suggest that there is subregional specificity within the PFC of rats, monkey and humans and there are parallel cognitive functions of the different subregions of the P FC in rats, monkeys and humans.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2011-10-01. It has received 342 citations till now. The article focuses on the topics: Working memory & Executive functions.read more
Citations
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The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
Bruce S. McEwen,John H. Morrison +1 more
TL;DR: The prefrontal cortex is involved in working memory and self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued.
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The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear.
Thomas F. Giustino,Stephen Maren +1 more
TL;DR: A division of labor has been proposed in which the prelimbic (PL) and infralimbic (IL) subdivisions of the medial prefrontal cortex (mPFC) regulate the expression and suppression of fear in rodents, respectively.
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A Review of the Pathophysiology, Etiology, and Treatment of Attention-Deficit Hyperactivity Disorder (ADHD)
Alok Sharma,Justin Couture +1 more
TL;DR: This review focuses on the pathophysiology, etiology, and treatment of ADHD and details the adverse effects and drug interaction profiles of the drugs used to treat it.
Journal ArticleDOI
The hippocampal-prefrontal pathway: The weak link in psychiatric disorders?
TL;DR: The H-PFC pathway is a potentially crucial element of the pathophysiology of several psychiatric diseases, and it offers a specific target for therapeutic intervention, which is consistent with the recent emphasis on reframing psychiatric diseases in terms of brain circuits.
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The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition
Sheree F. Logue,Thomas J. Gould +1 more
TL;DR: This review will examine the influence of dopamine, norepinephrine, serotonin, and acetylcholine on the following measures of executive function: attention, cognitive flexibility, and impulse control and the effects of polymorphisms in genes associated with these neurotransmitter systems on these measures.
References
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Ventrolateral prefrontal cortex lesions in rats impair the acquisition and retention of a tactile-olfactory configural task
TL;DR: Rats with aspirative lesions of the ventrolateral frontal cortex were tested on acquisition and postsurgical retention of an associative learning task that required that they learn a tactile-olfactory configural discrimination and the results imply that the prefrontal cortex is involved in at least certain types of cross-modal configural associativeLearning.
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The prefrontal cortex and variants of sequential behaviour: indications of functional differentiation between subdivisions of the rat's prefrontal cortex
Jesper Mogensen,Søren Holm +1 more
TL;DR: Lesions within the anteromedial, prefrontal cortex (especially if including the ventral part of this region) are associated with significantly impaired performance of both the presently investigated tasks.
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Cerebral correlates of explicit sequence learning
Arnaud Destrebecqz,Philippe Peigneux,Steven Laureys,Christian Degueldre,Guy Del Fiore,Joël Aerts,André Luxen,Martial Van der Linden,Axel Cleeremans,Pierre Maquet,Pierre Maquet +10 more
TL;DR: Results show that the metabolic response in the anterior cingulate/mesial prefrontal cortex (ACC/MPFC) is exclusively and specifically correlated with the explicit component of performance during recollection of a learned sequence, suggesting a significant role for the ACC/ MPFC in the explicit processing of sequential material.
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Large and small medial frontal cortex lesions and spatial performance of the rat
TL;DR: The results confirm the hypothesis that a strong relationship exists between medial frontal cortex lesion features (depth and length) and performance and suggest that this part of the brain functions as more than simply a spatial analyzer.