Journal ArticleDOI
An analysis of rat prefrontal cortex in mediating executive function.
TLDR
The data suggest that there is subregional specificity within the PFC of rats, monkey and humans and there are parallel cognitive functions of the different subregions of the P FC in rats, monkeys and humans.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2011-10-01. It has received 342 citations till now. The article focuses on the topics: Working memory & Executive functions.read more
Citations
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The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
Bruce S. McEwen,John H. Morrison +1 more
TL;DR: The prefrontal cortex is involved in working memory and self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued.
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The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear.
Thomas F. Giustino,Stephen Maren +1 more
TL;DR: A division of labor has been proposed in which the prelimbic (PL) and infralimbic (IL) subdivisions of the medial prefrontal cortex (mPFC) regulate the expression and suppression of fear in rodents, respectively.
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A Review of the Pathophysiology, Etiology, and Treatment of Attention-Deficit Hyperactivity Disorder (ADHD)
Alok Sharma,Justin Couture +1 more
TL;DR: This review focuses on the pathophysiology, etiology, and treatment of ADHD and details the adverse effects and drug interaction profiles of the drugs used to treat it.
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The hippocampal-prefrontal pathway: The weak link in psychiatric disorders?
TL;DR: The H-PFC pathway is a potentially crucial element of the pathophysiology of several psychiatric diseases, and it offers a specific target for therapeutic intervention, which is consistent with the recent emphasis on reframing psychiatric diseases in terms of brain circuits.
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The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition
Sheree F. Logue,Thomas J. Gould +1 more
TL;DR: This review will examine the influence of dopamine, norepinephrine, serotonin, and acetylcholine on the following measures of executive function: attention, cognitive flexibility, and impulse control and the effects of polymorphisms in genes associated with these neurotransmitter systems on these measures.
References
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Dopamine Modulation of Hippocampal–Prefrontal Cortical Interaction Drives Memory-Guided Behavior
Yukiori Goto,Anthony A. Grace +1 more
TL;DR: It is found that retrospective memory is mainly processed in the hippocampus but that this retrospective information must be incorporated within the prefrontal cortex (PFC) to be used to switch to an anticipatory response strategy involving prospective memory.
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Working memory in another dimension: functional imaging of human olfactory working memory.
TL;DR: The findings support the idea that working memory processes engage frontal cortical areas independent of the modality of input, but do not rule out the possibility of modality-specific neural populations within dorsolateral or ventrolateral cortex.
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Short-term memory for food reward magnitude: The role of the prefrontal cortex
TL;DR: The results indicate that the agranular insular cortex may play an important role in the processing of affect-laden information within a prefrontal cortex short-term or working memory system.
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Right Ventromedial and Dorsolateral Prefrontal Cortices Mediate Adaptive Decisions under Ambiguity by Integrating Choice Utility and Outcome Evaluation
TL;DR: It is proposed that these two prefrontal areas mediate shifting away from disadvantageous choices through their sensitivity to accumulating negative outcomes, and functional evidence of the underlying processes by which these prefrontal subregions drive adaptive choice in the task is provided through contingency-sensitive outcome evaluation.
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The roles of the medial prefrontal cortex and hippocampus in a spatial paired-association task
Inah Lee,Frances Solivan +1 more
TL;DR: The results confirm that the hippocampus is necessary for a biconditional paired-associate task when space is a critical component, and the mPFC, however, is more selectively involved in the object-in-place paired-Associate task than in the location-place pair-associ task.