Journal ArticleDOI
An analysis of rat prefrontal cortex in mediating executive function.
TLDR
The data suggest that there is subregional specificity within the PFC of rats, monkey and humans and there are parallel cognitive functions of the different subregions of the P FC in rats, monkeys and humans.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2011-10-01. It has received 342 citations till now. The article focuses on the topics: Working memory & Executive functions.read more
Citations
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The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
Bruce S. McEwen,John H. Morrison +1 more
TL;DR: The prefrontal cortex is involved in working memory and self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued.
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The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear.
Thomas F. Giustino,Stephen Maren +1 more
TL;DR: A division of labor has been proposed in which the prelimbic (PL) and infralimbic (IL) subdivisions of the medial prefrontal cortex (mPFC) regulate the expression and suppression of fear in rodents, respectively.
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A Review of the Pathophysiology, Etiology, and Treatment of Attention-Deficit Hyperactivity Disorder (ADHD)
Alok Sharma,Justin Couture +1 more
TL;DR: This review focuses on the pathophysiology, etiology, and treatment of ADHD and details the adverse effects and drug interaction profiles of the drugs used to treat it.
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The hippocampal-prefrontal pathway: The weak link in psychiatric disorders?
TL;DR: The H-PFC pathway is a potentially crucial element of the pathophysiology of several psychiatric diseases, and it offers a specific target for therapeutic intervention, which is consistent with the recent emphasis on reframing psychiatric diseases in terms of brain circuits.
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The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition
Sheree F. Logue,Thomas J. Gould +1 more
TL;DR: This review will examine the influence of dopamine, norepinephrine, serotonin, and acetylcholine on the following measures of executive function: attention, cognitive flexibility, and impulse control and the effects of polymorphisms in genes associated with these neurotransmitter systems on these measures.
References
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The contribution of the rat prelimbic-infralimbic areas to different forms of task switching.
TL;DR: The selective deficits observed in the odor-place tests suggest that the prelimbic-infralimbic areas enable behavioral flexibility when conditions demand inhibiting the use of one type of attribute information and learning a new type ofattribute information.
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Item and order dissociation in humans with prefrontal cortex damage
TL;DR: The data suggest that the prefrontal cortex mediates temporal order information for all modalities tested as well as item recognition memory for egocentric spatial information.
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Prefrontal unit activity during delayed alternation in the monkey. II. Relation to absolute versus relative direction of response
TL;DR: In this paper, single unit activity was recorded from the area principalis of the dorsolateral prefrontal cortex during DA in 3 monkeys in order to analyze further the nature of observed differential changes in relation to the different positions of the choice keys (directional selectivity).
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Differential Contributions of the Primate Ventrolateral Prefrontal and Orbitofrontal Cortex to Serial Reversal Learning
TL;DR: Posturgery, VLPFC lesioned animals were impaired in performing a series of discrimination reversals, but only when novel visual stimuli were introduced, and together, these data demonstrate the heterogeneous but interrelated involvement of primate OFC and V LPFC in the performance of serial reversal learning.
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Interactions between the prefrontal cortex and amygdala during delay discounting and reversal.
TL;DR: The current investigation found that inactivation and disconnection of the medial prefrontal cortex and basolateral amygdala led rats to become more impulsive by affecting preference for smaller immediate over larger delayed rewards.