Journal ArticleDOI
An analysis of rat prefrontal cortex in mediating executive function.
TLDR
The data suggest that there is subregional specificity within the PFC of rats, monkey and humans and there are parallel cognitive functions of the different subregions of the P FC in rats, monkeys and humans.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2011-10-01. It has received 342 citations till now. The article focuses on the topics: Working memory & Executive functions.read more
Citations
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Frontostriatal systems comprising connections between ventral medial prefrontal cortex and nucleus accumbens subregions differentially regulate motor impulse control in rats.
Malte Feja,Michael Koch +1 more
TL;DR: The results extend previous findings indicating the functional specialisation of frontostriatal networks and show a differential contribution of specific vmPFC-NAc connections to behavioural control depending on the NAc subregion.
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Neurobiology of ADHD: A Review
TL;DR: The intertwined relationship between different parts of the brain in patients with ADHD along with neurochemical and genetic basis of this disease are summarized.
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Altruistic and self-serving goals modulate behavioral and neural responses in deception.
TL;DR: Investigating the neural processes associated with spontaneous deception that occurs with altruistic reasons and self-serving reasons shed light on the neural basis of ‘good lies’ and decision-making in mutually beneficial situations.
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Strategic neuronal encoding in medial prefrontal cortex of spatial working memory in the T-maze.
Yang Yang,Richard B. Mailman +1 more
TL;DR: In this article, the authors found that neurons increased their firing rate around choice, with the increase largely occurring before choice as a prospective encode of behavior, which could be classified as sensitive-to-spatial information or sensitive to choice outcome.
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Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy
TL;DR: This work aimed to address causal links between α‐synuclein‐driven pathology in the cerebral cortex and the development of cognitive impairments using new experimental models.
References
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Journal ArticleDOI
An integrative theory of prefrontal cortex function
Earl K. Miller,Jonathan D. Cohen +1 more
TL;DR: It is proposed that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them, which provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task.
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Insensitivity to future consequences following damage to human prefrontal cortex
TL;DR: Using a novel task which simulates real-life decision-making in the way it factors uncertainty of premises and outcomes, as well as reward and punishment, it is found that prefrontal patients are oblivious to the future consequences of their actions, and seem to be guided by immediate prospects only.
Book
The Cognitive Neurosciences
TL;DR: The fourth edition of The Cognitive Neurosciences continues to chart new directions in the study of the biologic underpinnings of complex cognition -the relationship between the structural and physiological mechanisms of the nervous system and the psychological reality of the mind as discussed by the authors.
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Specific impairments of planning
TL;DR: An information-processing model is outlined that predicts that performance on non-routine tasks can be impaired independently of performance on routine tasks, related to views on frontal lobe functions, particularly those of Luria.
Journal ArticleDOI
Separate Neural Systems Value Immediate and Delayed Monetary Rewards
TL;DR: The authors examined the neural correlates of time discounting while subjects made a series of choices between monetary reward options that varied by delay to delivery and demonstrated that two separate systems are involved in such decisions.