Journal ArticleDOI
An analysis of rat prefrontal cortex in mediating executive function.
TLDR
The data suggest that there is subregional specificity within the PFC of rats, monkey and humans and there are parallel cognitive functions of the different subregions of the P FC in rats, monkeys and humans.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2011-10-01. It has received 342 citations till now. The article focuses on the topics: Working memory & Executive functions.read more
Citations
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Journal ArticleDOI
The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
Bruce S. McEwen,John H. Morrison +1 more
TL;DR: The prefrontal cortex is involved in working memory and self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued.
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The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear.
Thomas F. Giustino,Stephen Maren +1 more
TL;DR: A division of labor has been proposed in which the prelimbic (PL) and infralimbic (IL) subdivisions of the medial prefrontal cortex (mPFC) regulate the expression and suppression of fear in rodents, respectively.
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A Review of the Pathophysiology, Etiology, and Treatment of Attention-Deficit Hyperactivity Disorder (ADHD)
Alok Sharma,Justin Couture +1 more
TL;DR: This review focuses on the pathophysiology, etiology, and treatment of ADHD and details the adverse effects and drug interaction profiles of the drugs used to treat it.
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The hippocampal-prefrontal pathway: The weak link in psychiatric disorders?
TL;DR: The H-PFC pathway is a potentially crucial element of the pathophysiology of several psychiatric diseases, and it offers a specific target for therapeutic intervention, which is consistent with the recent emphasis on reframing psychiatric diseases in terms of brain circuits.
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The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition
Sheree F. Logue,Thomas J. Gould +1 more
TL;DR: This review will examine the influence of dopamine, norepinephrine, serotonin, and acetylcholine on the following measures of executive function: attention, cognitive flexibility, and impulse control and the effects of polymorphisms in genes associated with these neurotransmitter systems on these measures.
References
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Single-cell and population coding of expected reward probability in the orbitofrontal cortex of the rat.
E. van Duuren,G. van der Plasse,Jan Lankelma,Ruud N. J. M. A. Joosten,Matthijs G. P. Feenstra,Cyriel M. A. Pennartz +5 more
TL;DR: A population analysis using template matching as reconstruction method indicated that OFC generates a distributed representation of reward probability with a weak dependence on neuronal group size and confirmed that predictive information coded by OFC populations was quantitatively related to reward probability, but not to uncertainty.
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Bilateral destruction of the ventrolateral orbital cortex produces allocentric but not egocentric spatial deficits in rats
TL;DR: The results indicated that the VLO operates were significantly impaired in the cheeseboard task (allocentric task) relative to controls, but displayed no deficits in the adjacent-arm maze (egocentric task), a pattern of results similar to those found for the posterior parietal cortex.
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The role of the prefrontal cortex in object-place learning: a test of the attribute specificity model.
TL;DR: Whenever higher order processing is required to solve a task, the data support an attribute-specificity model of prefrontal cortex function in that the PL-IL cortices support both object and place attribute information in a variety of tasks including object-place paired associate learning.
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Neural mediation of memory for time: Role of the hippocampus and medial prefrontal cortex
TL;DR: There is a clear parallel between animals and humans in terms of hippocampal and prefrontal cortex mediation of the temporal attribute, supporting the assumption of evolutionary continuity and the development of new paradigms to measure memory for different temporal features.
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Activation of the prefrontal cortex during judgments of recency: a functional MRI study.
TL;DR: This study provides further evidence that memory for temporal context requires the prefrontal cortex and is the first to demonstrate this association in healthy humans and suggests the possibility that recognition of context and recognition of episodic content may involve similar brain systems.