Journal ArticleDOI
An analysis of rat prefrontal cortex in mediating executive function.
TLDR
The data suggest that there is subregional specificity within the PFC of rats, monkey and humans and there are parallel cognitive functions of the different subregions of the P FC in rats, monkeys and humans.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2011-10-01. It has received 342 citations till now. The article focuses on the topics: Working memory & Executive functions.read more
Citations
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Journal ArticleDOI
Neuronal and brain morphological changes in animal models of schizophrenia.
TL;DR: This review evaluates changes in spine density and dendritic arborization in animal models of schizophrenia to understand how pharmacological treatments can be designed to target specific neural systems to attenuate neuronal remodeling and associated behavioral deficits.
Journal ArticleDOI
Alcohol, stress hormones, and the prefrontal cortex: A proposed pathway to the dark side of addiction
Yi-Ling Lu,Heather N. Richardson +1 more
TL;DR: A pathway is proposed by which alcohol and stress hormones elicit neuroadaptive changes in prefrontal circuitry that could contribute functionally to a dampened neuroendocrine state and the increased propensity to relapse-a spiraling trajectory that could eventually lead to dependence.
Journal ArticleDOI
NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning.
TL;DR: It is shown that NR2A- containing NMDARs mediate trace, delay, and contextual fear memories, but NR2B-containing N MDARs are required only for trace conditioning, consistent with a role for PL mPFC in working memory.
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Disrupting the medial prefrontal cortex alters hippocampal sequences during deliberative decision making
TL;DR: The data suggest that the mPFC likely provides an important component to the initiation of deliberative sequences and provides support for an episodic-future thinking, working memory interpretation of deliberation.
Journal ArticleDOI
The other side of the histamine H3 receptor.
TL;DR: The anatomy and function of H3 receptors within the basal ganglia are described with a specific focus on their colocalization with dopamine D1 and D2 receptors and the therapeutic potential of drugs targeting H3 receptor in the treatment of Parkinson disease, schizophrenia, and addiction is discussed.
References
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Journal ArticleDOI
An integrative theory of prefrontal cortex function
Earl K. Miller,Jonathan D. Cohen +1 more
TL;DR: It is proposed that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them, which provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task.
Journal ArticleDOI
Insensitivity to future consequences following damage to human prefrontal cortex
TL;DR: Using a novel task which simulates real-life decision-making in the way it factors uncertainty of premises and outcomes, as well as reward and punishment, it is found that prefrontal patients are oblivious to the future consequences of their actions, and seem to be guided by immediate prospects only.
Book
The Cognitive Neurosciences
TL;DR: The fourth edition of The Cognitive Neurosciences continues to chart new directions in the study of the biologic underpinnings of complex cognition -the relationship between the structural and physiological mechanisms of the nervous system and the psychological reality of the mind as discussed by the authors.
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Specific impairments of planning
TL;DR: An information-processing model is outlined that predicts that performance on non-routine tasks can be impaired independently of performance on routine tasks, related to views on frontal lobe functions, particularly those of Luria.
Journal ArticleDOI
Separate Neural Systems Value Immediate and Delayed Monetary Rewards
TL;DR: The authors examined the neural correlates of time discounting while subjects made a series of choices between monetary reward options that varied by delay to delivery and demonstrated that two separate systems are involved in such decisions.