Journal ArticleDOI
An analysis of rat prefrontal cortex in mediating executive function.
TLDR
The data suggest that there is subregional specificity within the PFC of rats, monkey and humans and there are parallel cognitive functions of the different subregions of the P FC in rats, monkeys and humans.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2011-10-01. It has received 342 citations till now. The article focuses on the topics: Working memory & Executive functions.read more
Citations
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The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
Bruce S. McEwen,John H. Morrison +1 more
TL;DR: The prefrontal cortex is involved in working memory and self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued.
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The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear.
Thomas F. Giustino,Stephen Maren +1 more
TL;DR: A division of labor has been proposed in which the prelimbic (PL) and infralimbic (IL) subdivisions of the medial prefrontal cortex (mPFC) regulate the expression and suppression of fear in rodents, respectively.
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A Review of the Pathophysiology, Etiology, and Treatment of Attention-Deficit Hyperactivity Disorder (ADHD)
Alok Sharma,Justin Couture +1 more
TL;DR: This review focuses on the pathophysiology, etiology, and treatment of ADHD and details the adverse effects and drug interaction profiles of the drugs used to treat it.
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The hippocampal-prefrontal pathway: The weak link in psychiatric disorders?
TL;DR: The H-PFC pathway is a potentially crucial element of the pathophysiology of several psychiatric diseases, and it offers a specific target for therapeutic intervention, which is consistent with the recent emphasis on reframing psychiatric diseases in terms of brain circuits.
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The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition
Sheree F. Logue,Thomas J. Gould +1 more
TL;DR: This review will examine the influence of dopamine, norepinephrine, serotonin, and acetylcholine on the following measures of executive function: attention, cognitive flexibility, and impulse control and the effects of polymorphisms in genes associated with these neurotransmitter systems on these measures.
References
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A comparison of the effects of frontal cortical and thalamic lesions on measures of spatial learning and memory in the rat
TL;DR: Two experiments were conducted to compare the effects of radiofrequency lesions of thalamus and frontal cortex on three measures of spatial learning and memory: delayed non-matching to sample (DNMTS), radial arm maze with imposed delays, and serial reversal learning.
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Encoding the future: successful processing of intentions engages predictive brain networks.
TL;DR: While overall memory success was predicted by temporal lobe activations that included the hippocampus, PM success was also uniquely predicted by activations in additional regions, including left rostrolateral PFC and the right parahippocampal gyrus.
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Right prefrontal activation during encoding, but not during retrieval, in a non-verbal paired-associates task.
Torkel Klingberg,Per E. Roland +1 more
TL;DR: The lack of prefrontal activation during near-perfect performance of the retrieval task suggests that the prefrontal cortex is not necessarily active when retrieval is fast and accurate, or what might be called automatic.
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Memory for temporal order of new and familiar spatial location sequences: role of the medial prefrontal cortex.
TL;DR: The results support the idea that the medial prefrontal cortex contributes to mnemonic operations associated with temporal order for new and familiar spatial location information.
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Effort-Based Decision Making in the rat: An [18F]Fluorodeoxyglucose Micro Positron Emission Tomography Study
TL;DR: It is demonstrated that FDG-PET provides a tool to determine in rats regional brain metabolic activity in cognitive tasks and suggests that making decisions on how much effort to invest to obtain greater rewards evokes changes in multiple brain areas associated with cognitive, limbic, motor and autonomic functions.