An Updated Review of Tyrosinase Inhibitors
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TLDR
This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources and the inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.Abstract:
Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable. These phenomena have encouraged researchers to seek new potent tyrosinase inhibitors for use in foods and cosmetics. This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.read more
Citations
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Journal ArticleDOI
Inhibitory Effects of the Bioactive Thermorubin Isolated from the Fungus Thermoactinomyces Antibioticus on Melanogenesis
Shilpi Goenka,Sanford R. Simon +1 more
TL;DR: Preliminary results demonstrate that TR might offer a novel ingredient as a skin depigmenting agent for inclusion in cosmetic formulations and point to a mechanism of action of TR as an exclusive inhibitor of melanosome export.
Journal ArticleDOI
Design, synthesis of Cinnamyl-paeonol derivatives with 1, 3-Dioxypropyl as link arm and screening of tyrosinase inhibition activity in vitro.
Tang Kai,Yi Jiang,Huawei Zhang,Wenli Huang,Yundong Xie,Deng Chong,Hongbo Xu,Xiaomei Song,Xu Hong +8 more
TL;DR: The results indicated that compounds 8, 13 and 14 had better tyrosinase inhibitory activity and anti-melanogenesis activity and especially, the compound 13 has potentiality to develop novel tyosinase inhibitors and whitening agents.
Journal ArticleDOI
Thermodynamic, kinetic and docking studies of some unsaturated fatty acids-quercetin derivatives as inhibitors of mushroom tyrosinase
TL;DR: Computer simulations and experimental analysis demonstrated that the ligands increased the mushroom tyrosinase stability by reducing the activity of enzyme, and ligand I showed the potent inhibitory and played an important role in enzyme stability.
Journal ArticleDOI
Antioxidant and tyrosinase inhibition activities of α- mangostin and Garcinia mangostana Linn. pericarp extracts
Wan Nur Atiqah Wan Hassan,Razauden Mohamed Zulkifli,Norazah Basar,Farediah Ahmad,Mohd Azizi Che Yunus +4 more
TL;DR: In this paper, methanol, ethyl acetate and petroleum ether crude extracts of mangosteen pericarp and α- mangostin were evaluated for the antioxidant capacity and tyrosinase inhibition properties.
Journal ArticleDOI
Melanogenesis inhibition by a crude extract of Magnolia officinalis
TL;DR: MOE was proven to be a good candidate as a skin-whitening agent for treatment of skin hyperpigmentation by demonstrating that MOE inhibits melanogenesis of B16 cells by a pre-translational regulation on tyrosinase gene expression.
References
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Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future.
Y.-J. Kim,Hiroshi Uyama +1 more
TL;DR: This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance, and examines the role of tyrosinase in melanin biosynthesis and its role in dermatological disorders.
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Chemical and Instrumental Approaches to Treat Hyperpigmentation
TL;DR: This review describes the different approaches to obtain depigmentation, suggests a classification of whitening molecules on the basis of the mechanism by which they interfere with melanogenesis, and confirms the necessity to apply standardized protocols to evaluate depigmenting treatments.
Journal ArticleDOI
Mushroom Tyrosinase: Recent Prospects
TL;DR: A study on the importance of tyrosinase, especially that derived from mushroom, and describes its biochemical character and inhibition and activation by the various chemicals obtained from natural and synthetic origins with its clinical and industrial importance in the recent prospects.
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