An Updated Review of Tyrosinase Inhibitors
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This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources and the inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.Abstract:
Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable. These phenomena have encouraged researchers to seek new potent tyrosinase inhibitors for use in foods and cosmetics. This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.read more
Citations
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Identifikasi Aktivitas Inhibitor Enzim Tirosinase Senyawa Turunan Flavonoid pada Kulit Buah Cokelat (Theobroma cacao L) secara In Silico
TL;DR: In this paper, the authors evaluated the molecular interaction between flavonoids from cocoa pod husk with tyrosinase enzyme using in silico molecular docking method, which was carried out through several stages, including preparation of enzyme macromolecules, identifying and evaluating molecular docking, and molecular dynamics simulations of the test compound with the enzyme molecule.
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Characterization of Four New Compounds from Protea cynaroides Leaves and Their Tyrosinase Inhibitory Potential
Masande Nicholas Yalo,Masixole Makhaba,A.A. Hussein,Rajan Sharma,Mkhuseli Koki,Ndikho Nako,Wilfred T. Mabusela +6 more
TL;DR: In this article , the leaves of Protea cynaroides were air-dried at room temperature, powdered, and extracted with 80% methanol followed by solvent fractionation (hexane, dichloromethane, ethyl acetate, and butanol).
Journal ArticleDOI
Reply to comments on ‘Lavender and peppermint essential oils as effective mushroom tyrosinase inhibitors: a basic study’, D. Fiocco, D. Fiorentino, L. Frabboni, S. Benvenuti, G. Orlandini, F. Pellati, A. Gallone, Flavour Fragr. J. 2011, 26, 441–446
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Whitening effect of kojic acid dipalmitate loaded nanosized ethosomal gel for the treatment of hyperpigmentation: In vitro and in vivo characterization
TL;DR: Ethosomal gel gives significant decrease in skin melanin, erythema, and sebum level while it causes improvement in skin hydration level and elasticity during non-invasive in-vivo studies and provides deep penetration of KAD into the skin.
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Metabolite profiling reveals comprehensive effects of Chaetomium globosum on citrus preservation
TL;DR: In this paper , a biocontrol fungus Chaetomium globosum QY-1 near the orchard in riparian area was identified to have antimicrobial, antioxidant and tyrosinase inhibition activity, which meets the requirements of an ideal preservative.
References
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Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future.
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TL;DR: This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance, and examines the role of tyrosinase in melanin biosynthesis and its role in dermatological disorders.
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Chemical and Instrumental Approaches to Treat Hyperpigmentation
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Mushroom Tyrosinase: Recent Prospects
TL;DR: A study on the importance of tyrosinase, especially that derived from mushroom, and describes its biochemical character and inhibition and activation by the various chemicals obtained from natural and synthetic origins with its clinical and industrial importance in the recent prospects.
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