An Updated Review of Tyrosinase Inhibitors
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TLDR
This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources and the inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.Abstract:
Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable. These phenomena have encouraged researchers to seek new potent tyrosinase inhibitors for use in foods and cosmetics. This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.read more
Citations
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Phytochemical Analysis, Antioxidant, Antibacterial, Cytotoxic, and Enzyme Inhibitory Activities of Hedychium flavum Rhizome.
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Spondias mombim L. (Anacardiaceae): Chemical fingerprints, inhibitory activities, and molecular docking on key enzymes relevant to erectile dysfunction and Alzheimer's diseases.
Oluwafemi Adeleke Ojo,Oluwafemi Adeleke Ojo,Adeola Agnes Afon,Adebola Busola Ojo,Basiru Olaitan Ajiboye,Mary Abiola Okesola,Raphael Taiwo Aruleba,Tayo Alex Adekiya,Babatunji Emmanuel Oyinloye,Babatunji Emmanuel Oyinloye +9 more
TL;DR: The results suggested that SMEAF could be explored as phytopharmaceuticals as well as green vegetable with enormous medicinal value probably due to its polyphenols with potent antioxidant activity.
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Influence of rosmarinic acid and Salvia officinalis extracts on melanogenesis of B16F10 cells
TL;DR: Rosmarinic acid showed a dual behavior on melanogenesis, increasing melanin biosynthesis and tyrosinase activity at low concentrations and decreasing it at higher levels, which may be useful in further studies for therapeutic formulations to treat skin pigmentation disorders.
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Effects of phenanthrene on early development of the Pacific oyster Crassostrea gigas (Thunberg, 1789)
Diego José Nogueira,Jacó Joaquim Mattos,Patrick Rafael Dybas,Fabrício Flores-Nunes,Silvio Tarou Sasaki,Satie Taniguchi,Éder C. Schmidt,Zenilda L. Bouzon,Márcia C. Bícego,Cláudio Melo,Guilherme Toledo-Silva,Afonso Celso Dias Bainy +11 more
TL;DR: This is the first study to provide evidences that exposure to PHE can affect early oyster development at the molecular and morphological levels, possibly threatening this bivalve species.
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Tyrosinase immobilized enzyme reactor: development and evaluation.
TL;DR: The tyr-IMERs were successfully tested with known and potential inhibitors of tyrosinase, and the results showed that they can be used for the screening of inhibitors of that enzyme.
References
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Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future.
Y.-J. Kim,Hiroshi Uyama +1 more
TL;DR: This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance, and examines the role of tyrosinase in melanin biosynthesis and its role in dermatological disorders.
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Chemical and Instrumental Approaches to Treat Hyperpigmentation
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Mushroom Tyrosinase: Recent Prospects
TL;DR: A study on the importance of tyrosinase, especially that derived from mushroom, and describes its biochemical character and inhibition and activation by the various chemicals obtained from natural and synthetic origins with its clinical and industrial importance in the recent prospects.
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