An Updated Review of Tyrosinase Inhibitors
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TLDR
This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources and the inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.Abstract:
Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable. These phenomena have encouraged researchers to seek new potent tyrosinase inhibitors for use in foods and cosmetics. This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.read more
Citations
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Journal ArticleDOI
Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12.
Miri Lee,Hyeonji Park,Sea Wha Jeon,Jeong Kyu Bang,Ka Young Chung,Dal Woong Choi,Eun-Joo Kim,Kyung Min Lim +7 more
TL;DR: It is demonstrated that new hexa-peptoids, PAL-10 and PAL-12, can inhibit melanogenesis in B16F10 melanoma cells, a 3D pigmented human skin model and zebrafish and can be used as a new cosmetic ingredient with strong brightening efficacies.
Journal ArticleDOI
The Molecular Basis of Chemical Chaperone Therapy for Oculocutaneous Albinism Type 1A.
Ayako Teramae,Yui Kobayashi,Hiroyuki Kunimoto,Koichi Nakajima,Tamio Suzuki,Daisuke Tsuruta,Kazuyoshi Fukai +6 more
TL;DR: The possibility of chemical chaperone therapy for Japanese patients with OCA type 1A missense mutations is explored and it is found that HeLa cells expressing P431L mutant tyrosinase have restored tyosinase activity after treatment with a low-dose tyros in a dose-dependent manner.
Journal ArticleDOI
Design, synthesis, in vitro evaluation and molecular docking study of N'-Arylidene imidazo [1,2-a] pyridine -2-carbohydrazide derivatives as novel Tyrosinase inhibitors
Tahereh Damghani,Saba Hadaegh,Mahsima Khoshneviszadeh,Somayeh Pirhadi,Razieh Sabet,Mehdi Khoshneviszadeh,Najmeh Edraki +6 more
TL;DR: It was found that compounds bearing 3-nitro (6j) and 4‑hydroxy (6g) moieties on the arylidene pendant exhibited the best Tyrosinase inhibitory activity with IC50 values of 7.19 and 8.11 μM, respectively.
Patent
Skin whitening composition containing chia seed extract
TL;DR: In this article, a topical composition includes an alcohol-extracted Salvia hispanica seed extract in a glycol carrier in an amount effective for inhibiting melanin content in an individual.
Journal ArticleDOI
Transcriptome expression profiling of fur color formation in domestic rabbits using Solexa sequencing.
TL;DR: Solexa-sequencing technology was used to probe gene expression in dorsal skin tissues sampled from full-sibling Rex rabbits of different colors, and some genes that are related to fur formation were identified, including Tyrosinase-related protein 1 (TYRP1) and TyOSinase (TYR), as well as genes with unknown functions.
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TL;DR: This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance, and examines the role of tyrosinase in melanin biosynthesis and its role in dermatological disorders.
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