An Updated Review of Tyrosinase Inhibitors
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TLDR
This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources and the inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.Abstract:
Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable. These phenomena have encouraged researchers to seek new potent tyrosinase inhibitors for use in foods and cosmetics. This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.read more
Citations
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Journal ArticleDOI
Phloretin as both a substrate and inhibitor of tyrosinase: Inhibitory activity and mechanism
TL;DR: The results of spectroscopy and chromatography indicate that phloretin is a substrate of tyrosinase but also an inhibitor, and the possible inhibitory mechanism is proposed, which will be helpful to design and search for tyosinase inhibitors.
Journal ArticleDOI
The influence of hydroquinone on tyrosinase kinetics.
TL;DR: In vitro studies demonstrate that hydroquinone is not a primary substrate for tyrosinase action but is vicariously oxidised by a redox exchange mechanism in the presence of either catechol, L-3,4-dihydroxyphenylalanine or 4-ethylphenol.
Patent
Method and apparatus for skin resurfacing
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Cellular Anti-Melanogenic Effects of a Euryale ferox Seed Extract Ethyl Acetate Fraction via the Lysosomal Degradation Machinery.
TL;DR: It is suggested that Efse-EA may contribute to the inhibition of melanogenesis by altering lysosomal degradation of tyrosinase, and that this extract may provide a new cosmetic skin-whitening agent.
Journal ArticleDOI
Melanogenesis inhibitory activity of a 7-O-9′-linked neolignan from Alpinia galanga fruit
Yoshiaki Manse,Kiyofumi Ninomiya,Ryosuke Nishi,Iyori Kamei,Yushi Katsuyama,Takahito Imagawa,Saowanee Chaipech,Osamu Muraoka,Toshio Morikawa +8 more
TL;DR: An aqueous acetone extract from the fruit of Alpinia galanga demonstrated inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells, and the active compounds 1-3 inhibited tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA expressions could be the mechanism of melanogenesis inhibitory activity.
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Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future.
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TL;DR: This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance, and examines the role of tyrosinase in melanin biosynthesis and its role in dermatological disorders.
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Chemical and Instrumental Approaches to Treat Hyperpigmentation
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