An Updated Review of Tyrosinase Inhibitors
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TLDR
This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources and the inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.Abstract:
Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable. These phenomena have encouraged researchers to seek new potent tyrosinase inhibitors for use in foods and cosmetics. This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.read more
Citations
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Anti-melanogenesis and antigenotoxic activities of eriodictyol in murine melanoma (B16-F10) and primary human keratinocyte cells.
Mokdad-Bzeouich Imen,Fadwa Chaabane,Mustapha Nadia,Kilani-Jaziri Soumaya,Ghedira Kamel,Chekir-Ghedira Leila +5 more
TL;DR: It appears that 50 μM of eriodictyol solution suppressed H2O2 induced genotoxicity and revealed a significant cellular antioxidant capacity against reactive oxygen species formation in B16-F10 and PHK cells, which could be introduced as a natural skin depigmenting agent in skin care products.
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Safflospermidines from the bee pollen of Helianthus annuus L. exhibit a higher in vitro antityrosinase activity than kojic acid
TL;DR: Ozone deterioration in the atmosphere has become a severe problem causing overexposure of ultraviolet light, which results in humans in melanin overproduction and can lead to many diseases, such as skin cancer and melasma, as well as undesirable esthetic appearances,such as freckles and hyperpigmentation.
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Block copolymer nanoparticles-based fluorescent sensor for ultrasensitive detection of tyrosinase activity and inhibitor
Ying Liu,Chong-Hua Zhang,Chong-Hua Zhang,Peisheng Zhang,Peisheng Zhang,Hong Wang,Jin-Wen Liu,Shenglan Wang,Rongjin Zeng,Shu Chen,Jian Chen +10 more
TL;DR: A novel fluorescent biosensor strategy has been developed capable of sensitive, label-free and rapid screening of tyrosinase activity as well as corresponding inhibitors based on fluorescent block copolymer nanoparticles (BCNs) and may provide a novel platform for biosensor development.
Journal ArticleDOI
Identification of p-hydroxybenzyl alcohol, tyrosol, phloretin and its derivate phloridzin as tyrosinase substrates.
Carmen Vanessa Ortiz-Ruiz,Jose Berna,Maria del Mar Garcia-Molina,José Tudela,Virginia Tomás,Francisco García-Cánovas +5 more
TL;DR: This study demonstrates that the hydroxyalkylphenols p-hydroxybenzyl alcohol and tyrosol, and the compound phloretin and its derivate phloridzin are not true inhibitors but alternative substrates of the enzyme tyrosinase.
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Composition and biological activities of different extracts of Salvia jurisicii, a rare and endemic Macedonian species
Ana Alimpić,Aleksandar Knežević,Katarina Šavikin,Milena G. Curcic,Dragan T. Veličković,Tatjana Stević,Vlado Matevski,Mirjana Stajić,Snežana D. Marković,Petar D. Marin,Sonja Duletic-Lausevic +10 more
TL;DR: In this article, the phenolic composition and biological activities of Salvia jurisicii Kosanin (Lamiaceae) originating from Macedonia were analyzed using HPLC-DAD, while the antioxidant activity of extracts was studied using 2,2-dyphenyl-1-picrylhydrazyl, 2 2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ferric reducing ability of plasma and s-carotene bleaching assays.
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TL;DR: This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance, and examines the role of tyrosinase in melanin biosynthesis and its role in dermatological disorders.
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