An Updated Review of Tyrosinase Inhibitors
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TLDR
This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources and the inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.Abstract:
Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable. These phenomena have encouraged researchers to seek new potent tyrosinase inhibitors for use in foods and cosmetics. This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.read more
Citations
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A novel synthetic compound, (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-iminothiazolidin-4-one (MHY773) inhibits mushroom tyrosinase.
Hee Jin Jung,Min Jung Lee,Yeo Jin Park,Sang Gyun Noh,A Kyoung Lee,Kyoung Mi Moon,Eun Kyeong Lee,Eun Jin Bang,Yun Jung Park,Su Jeong Kim,Jungho Yang,Sultan Ullah,Pusoon Chun,Young Suk Jung,Hyung Ryong Moon,Hae Young Chung +15 more
TL;DR: Data suggest that MHY773 suppressed the melanin production via the inhibition of tyrosinase activity, and is a promising for the development of effective pharmacological and cosmetic agents for skin-whitening.
Journal ArticleDOI
Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy.
Ki-Won Lee,Hyung Won Ryu,Sang-Seok Oh,Soojong Park,Hamadi Madhi,Jiyun Yoo,Ki-Hun Park,Kwang Dong Kim +7 more
TL;DR: The results suggest that β‐mangostin inhibits the melanogenesis induced by α‐MSH via an autophagy‐dependent mechanism, and thus, the depigmentation effect of α‐melanocyte‐stimulating hormone‐mediated melanogenesis may depend on autophile targeted at the melanosome rather than non‐selective autophagic.
Journal ArticleDOI
Inhibition of tyrosinase activity and melanin production by the chalcone derivative 1-(2-cyclohexylmethoxy-6-hydroxy-phenyl)-3-(4-hydroxymethyl-phenyl)-propenone
TL;DR: Chalcone-21 strongly inhibited cellular melanin production and tyrosinase activity in B16F10 melanoma cells stimulated with α-melanocyte stimulating hormone (α-MSH) or protoporphyrin IX and was demonstrated to be an effective depigmenting agent.
Journal ArticleDOI
Advances in the Tyrosinase Inhibitors from Plant Source
TL;DR: Recent trends in the discovery of tyrosinase inhibitors from plant sources are reported to provide a rationale for the continued study of natural tyrosINase inhibitors, and to recognise the potential therapeutic rewards associated with the identification of these agents.
Journal ArticleDOI
The effect of time and origin of harvest on the in vitro biological activity of Palmaria palmata protein hydrolysates
TL;DR: The results show that Palmaria palmata hydrolysates may have potential applications as health enhancing ingredients and as food preservatives due to their antioxidant and tyrosinase inhibitory effects.
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TL;DR: This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance, and examines the role of tyrosinase in melanin biosynthesis and its role in dermatological disorders.
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