Journal ArticleDOI
Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis.
Shasha Luo,He Li,Jingjing Liu,Xiaoqian Xie,Zhijie Wan,Yale Wang,Zeyue Zhao,Xiaohan Wu,Xinxin Li,Min Yang,Xiaotian Li +10 more
TLDR
Andrographolide acts as a protective agent for the treatment of complete freund's adjuvant induced rheumatoid arthritis by inhibiting lipid peroxidation and nitrite/nitrate levels in a dose-dependent manner, enhancing antioxidant enzyme activity, reducing levels of chemokines and inflammatory factors, preventing neutrophil accumulation and infiltration.About:
This article is published in Chemico-Biological Interactions.The article was published on 2020-03-01. It has received 29 citations till now. The article focuses on the topics: Andrographolide & Arthritis.read more
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Traditional herbal medicine: Therapeutic potential in rheumatoid arthritis.
Yuan Wang,Shujing Chen,Kunze Du,Chunxiao Liang,Shuangqi Wang,Evans Owusu Boadi,Jin Li,Xiaoli Pang,Jun He,Yan-xu Chang +9 more
TL;DR: In this article, the authors provide a brief overview of the potential pharmacological mechanisms of THMs (active constituents, extracts, and prescriptions) in RA treatment, including anti-RA effects and therapeutic targets of distinct dosage forms of traditional herbal medicines (THMs).
Journal ArticleDOI
Plant-microbial interaction: The mechanism and the application of microbial elicitor induced secondary metabolites biosynthesis in medicinal plants.
Imane Chamkhi,Taoufiq Benali,Tarik Aanniz,Naoual El Menyiy,Fatima-Ezzahrae Guaouguaou,Nasreddine El Omari,Mohamed El-Shazly,Gokhan Zengin,Abdelhakim Bouyahya +8 more
TL;DR: In this paper, the impact of microbial elicitors on the synthesis and secretion of secondary metabolites in plants was highlighted, and biological properties of these bioactive compounds were also highlighted and discussed.
Journal ArticleDOI
Andrographolide and its derivatives: Current achievements and future perspectives.
TL;DR: A review of the potential of andrographolide and its derivatives in diverse diseases has been presented in this paper, highlighting the drug design, pharmacokinetic and mechanistic studies for the past ten years, together with a brief overview of the pharmacological effects.
Journal ArticleDOI
Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches.
TL;DR: Wang et al. as discussed by the authors presented a comprehensive review of andrographis paniculata (Burm. f. ex Nees), including its pharmacology, pharmacokinetics, toxicity and pharmaceutical researches.
Journal ArticleDOI
Natural medicines of targeted rheumatoid arthritis and its action mechanism
TL;DR: These natural medicines mainly include flavonoids, polyphenols, alkaloids, glycosides and terpenes are star natural medicines for the treatment of RA and their mechanisms of action are summarized.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
Journal ArticleDOI
Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
Mitsuru Uchiyama,Midori Mihara +1 more
TL;DR: It was concluded that the deproteinization of homogenate prior to coloration is not needed, but double wavelength measurement is necessary to avoid interference and the reaction should be performed with phosphoric acid at a definite pH near 2.0.
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Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker
TL;DR: It is demonstrated that MPO can be used as a marker for skin neutrophil content: it is recoverable from skin in soluble form, and is directly related to neutrophIL number.
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Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite
TL;DR: A dose threshold exists for bromobenzene-induced hepatic necrosis and it is demonstrated that the hepatotoxic metabolite is preferentially conjugated (detoxified) with glutathione, thereby depleting glutATHione from the liver.