Journal ArticleDOI
Anemia for risk assessment of patients with acute coronary syndromes.
Nicolas Meneveau,Francois Schiele,Marie-France Seronde,Vincent Descotes-Genon,Joanna Oettinger,Romain Chopard,Fiona Ecarnot,Jean-Pierre Bassand,Reseau de Cardiologie de Franche Comte +8 more
TLDR
The data confirmed that anemia was an independent predictive factor of mortality and had incremental predictive value to the GRACE score system for early clinical outcomes.Abstract:
In patients admitted with acute coronary syndromes, those with anemia are at higher risk. However, current risk score systems do not take into account the presence of anemia. The impact of anemia on mortality was studied, and its incremental predictive value was evaluated. Demographic, clinical, and biologic characteristics at admission, as well as treatments and mortality, were recorded for 1,410 consecutive patients with acute coronary syndromes. The incremental value of adding anemia information to risk score evaluation was determined using changes in the appropriateness of Cox models when anemia was added. Anemia was detected in 381 patients (27%). They were older, had more co-morbidities, had higher Global Registry of Acute Coronary Events (GRACE) risk scores, received fewer guideline-recommended treatments, and, as a result, had 4-fold higher mortality. When included in a prediction model based on the GRACE risk score, anemia remained an independent predictor of mortality. The addition of anemia improved both the discriminatory capacity and calibration of the models. According to the GRACE risk score, the population was divided into 4 groups of different risk levels ofread more
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Journal ArticleDOI
Anemia and mortality in acute coronary syndromes: A systematic review and meta-analysis
Patrick R. Lawler,Kristian B. Filion,Tara Dourian,Renée Atallah,Michael Garfinkle,Mark J. Eisenberg +5 more
TL;DR: Clinically and statistically significant increases in mortality were observed as early as at 30 days post-ACS and persisted at 1 year and anemia in patients with ACS is independently associated with a significantly increased risk of early and late mortality.
Journal Article
Anemia in Older Persons
TL;DR: Anemia in older persons is commonly overlooked despite mounting evidence that low hemoglobin levels are a significant marker of physiologic decline, and there is increasing evidence that even mild anemia is associated with increased morbidity and mortality.
Journal ArticleDOI
Use of reclassification for assessment of improved prediction: an empirical evaluation
TL;DR: Reclassification studies would benefit from more rigorous methodological standards; otherwise claims for improved reclassification may remain spurious.
Journal ArticleDOI
Is anemia a new cardiovascular risk factor
Georgia Kaiafa,Ilias Kanellos,Christos Savopoulos,Nikolaos Kakaletsis,George Giannakoulas,Apostolos I. Hatzitolios +5 more
TL;DR: This review aims to clarify poorly investigated and defined issues concerning the relation of anemia and cardiovascular risk--in particular in patients with acute coronary syndromes and chronic heart failure--as well as the current therapeutic strategies in these clinical conditions.
Journal ArticleDOI
Anemia and acute coronary syndrome: current perspectives.
TL;DR: Estimated prevalence of anemia on admission in the setting of an acute coronary syndrome (ACS) is between 10% and 43% of the patients depending upon the specific population under investigation, and up to 57% of ACS patients may develop hospital-acquired anemia (HAA), even if different mechanisms contribute to their prognostic impact.
References
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Elliott M. Antman,Jean-Pierre Bassand,Werner Klein,Magnus Ohman,José Luis López Sendón,Lars Rydén,Maarten L. Simoons,Michal Tendera +7 more
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Myocardial infarction redefined - A consensus document of the Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction
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A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: Development and initial validation
Roxana Mehran,Eve Aymong,Eugenia Nikolsky,Zoran Lasic,Ioannis Iakovou,Martin Fahy,Gary S. Mintz,Alexandra J. Lansky,Jeffrey W. Moses,Gregg W. Stone,Martin B. Leon,George Dangas +11 more
TL;DR: The risk of CIN after PCI can be simply assessed using readily available information and can be used for both clinical and investigational purposes.
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Predictors of hospital mortality in the global registry of acute coronary events.
Christopher B. Granger,Robert J. Goldberg,Omar H. Dabbous,Karen S. Pieper,Kim A. Eagle,Christopher P. Cannon,Frans Van de Werf,Alvaro Avezum,Shaun G. Goodman,Marcus Flather,Keith A.A. Fox +10 more
TL;DR: Across the entire spectrum of ACS and in general clinical practice, this model provides excellent ability to assess the risk for death and can be used as a simple nomogram to estimate risk in individual patients.
Journal ArticleDOI
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes
J.-P Bassand,Christian W. Hamm,Diego Ardissino,Eric Boersma,A Budaj,Francisco Fernández-Avilés,Keith A.A. Fox,David Hasdai,Erik Magnus Ohman,Lars Wallentin,William Wijns +10 more
TL;DR: Guidelines and Expert Consensus Documents summarize and evaluate all currently available evidence on a particular issue with the aim to assist physicians in selecting the best management strategies for a typical patient, suffering from a given condition, taking into account the impact on outcome, as well as the risk–benefit ratio of particular diagnostic or therapeutic means.