Journal ArticleDOI
Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders.
Monte S. Buchsbaum,Lynn E. DeLisi,Henry H. Holcomb,J. Cappelletti,A C King,Jeannette L. Johnson,Erin A. Hazlett,Susan Dowling-Zimmerman,Robert M. Post,John M. Morihisa,William T. Carpenter,Robert M. Cohen,David Pickar,Daniel R. Weinberger,Richard Margolin,R. M. Kessler +15 more
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TLDR
Local cerebral uptake of deoxyglucose labeled with fluorine 18 was measured by positron emission tomography in patients with schizophrenia and patients with affective disorder, sharing a lack of diagnostic specificity with many biologic measures.Citations
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Journal ArticleDOI
Glucose utilization in the temporal cortex of affectively ill patients: positron emission tomography.
Robert M. Post,Lynn E. DeLisi,Henry H. Holcomb,Thomas W. Uhde,Robert M. Cohen,Monte S. Buchsbaum +5 more
TL;DR: The lack of a significant increase in glucose utilization, measured either as a maximum or in relation to other areas in the PET scan slice, suggests that a temporal lobe activation or a seizure-like process is not generally occurring during active depressive phases of the illness.
Journal ArticleDOI
Brain imaging: applications in psychiatry
TL;DR: Various brain imaging techniques have become available in the past decade and they have enlarged the knowledge of the pathophysiology of mental illnesses by demonstrating structural, metabolic, and neurochemical abnormalities in a wide range of mental disorders.
Journal ArticleDOI
Dysfunction in a prefrontal substrate of sustained attention in schizophrenia
Robert M. Cohen,William E. Semple,Michael Gross,Thomas E. Nordahl,Lynn E. DeLisi,Henry H. Holcomb,A. Catherine King,John M. Morihisa,David Pickar +8 more
TL;DR: Findings point to a role of the mid-prefrontal region in sustained attention and to dysfunction of this region in schizophrenia.
Journal ArticleDOI
Cerebral glucose metabolic rates in normal human females versus normal males
Lewis R. Baxter,John C. Mazziotta,Michael E. Phelps,Carl Selin,Barry H. Guze,Lynn A. Fairbanks +5 more
TL;DR: The higher cerebral glucose metabolic rates observed in women may have been related to the effects of the high estrogen levels that can obtain in the phase of the menstrual cycle during which the authors tested their female subjects.
Journal ArticleDOI
What is dementia
TL;DR: The diagnosis of dementia implies that several mental faculties are involved and exclude isolated neuropsychiatrie disturbances such as amnesia and aphasia which occur with focal brain lesions.
References
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Manual for the State-Trait Anxiety Inventory
TL;DR: The STAI as mentioned in this paper is an indicator of two types of anxiety, the state and trait anxiety, and measure the severity of the overall anxiety level, which is appropriate for those who have at least a sixth grade reading level.
Journal ArticleDOI
The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.
Louis Sokoloff,Martin Reivich,Charles Kennedy,Charles Kennedy,M. H. Des Rosiers,Clifford S. Patlak,Karen D. Pettigrew,O. Sakurada,M. Shinohara +8 more
TL;DR: The method can be applied to most laboratory animals in the conscious state and is based on the use of 2‐deoxy‐D‐[14C]glucose as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues.
Journal ArticleDOI
A Diagnostic Interview: The Schedule for Affective Disorders and Schizophrenia
Jean Endicott,Robert L. Spitzer +1 more
TL;DR: Initial scale development and reliability studies of the items and the scale scores are reported on.
Journal ArticleDOI
Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method.
Michael E. Phelps,Michael E. Phelps,Sung-Cheng Huang,Sung-Cheng Huang,Edward J. Hoffman,Edward J. Hoffman,Carl Selin,Carl Selin,L. Sokoloff,L. Sokoloff,David E. Kuhl,David E. Kuhl +11 more
TL;DR: The data indicate that cerebral FDG‐6‐PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
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