Journal ArticleDOI
Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders.
Monte S. Buchsbaum,Lynn E. DeLisi,Henry H. Holcomb,J. Cappelletti,A C King,Jeannette L. Johnson,Erin A. Hazlett,Susan Dowling-Zimmerman,Robert M. Post,John M. Morihisa,William T. Carpenter,Robert M. Cohen,David Pickar,Daniel R. Weinberger,Richard Margolin,R. M. Kessler +15 more
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TLDR
Local cerebral uptake of deoxyglucose labeled with fluorine 18 was measured by positron emission tomography in patients with schizophrenia and patients with affective disorder, sharing a lack of diagnostic specificity with many biologic measures.Citations
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Journal ArticleDOI
Late positive component amplitude in schizophrenics and alcoholics in two different paradigms
TL;DR: Alcoholics and schizophrenics showed late positive components that were significantly reduced in amplitude compared to controls, and the patient groups were similar in their late component amplitudes.
Book ChapterDOI
Brain Imaging Studies of Depressive Disorders
Harold A. Sackeim,Isak Prohovnik +1 more
TL;DR: This chapter provides an overview of what has been learned from initial studies of brain imaging in affective disorders through in vivo measurement of brain structure and function.
Journal ArticleDOI
The Validity of the Assessment of Psychopathology in the Psychoses
TL;DR: This paper reviews recent progress in the assessment of the psychopathology of psychosis and focuses upon a number of persistent limitations, in particular the over-emphasis upon reliability at the expense of validity.
Journal ArticleDOI
Diffuse cortical reduction of neuronal activity in unipolar major depression: a retrospective analysis of 337 patients and 321 controls.
TL;DR: The data indicate a diffuse cortical rather than regionalized reduction of neuronal activity in unipolar major depression, in contrast to the current view.
Journal ArticleDOI
Regional cerebral blood flow alterations in unipolar depression.
TL;DR: Diagnostic-subtype-dependent age effects on rCBF precluded comparisons of mean values within or across regions for subject groups, but distinguished between symptomatic depressed patients and control subjects and among patient groups.
References
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Manual for the State-Trait Anxiety Inventory
TL;DR: The STAI as mentioned in this paper is an indicator of two types of anxiety, the state and trait anxiety, and measure the severity of the overall anxiety level, which is appropriate for those who have at least a sixth grade reading level.
Journal ArticleDOI
The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.
Louis Sokoloff,Martin Reivich,Charles Kennedy,Charles Kennedy,M. H. Des Rosiers,Clifford S. Patlak,Karen D. Pettigrew,O. Sakurada,M. Shinohara +8 more
TL;DR: The method can be applied to most laboratory animals in the conscious state and is based on the use of 2‐deoxy‐D‐[14C]glucose as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues.
Journal ArticleDOI
A Diagnostic Interview: The Schedule for Affective Disorders and Schizophrenia
Jean Endicott,Robert L. Spitzer +1 more
TL;DR: Initial scale development and reliability studies of the items and the scale scores are reported on.
Journal ArticleDOI
Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method.
Michael E. Phelps,Michael E. Phelps,Sung-Cheng Huang,Sung-Cheng Huang,Edward J. Hoffman,Edward J. Hoffman,Carl Selin,Carl Selin,L. Sokoloff,L. Sokoloff,David E. Kuhl,David E. Kuhl +11 more
TL;DR: The data indicate that cerebral FDG‐6‐PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
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