Journal ArticleDOI
Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders.
Monte S. Buchsbaum,Lynn E. DeLisi,Henry H. Holcomb,J. Cappelletti,A C King,Jeannette L. Johnson,Erin A. Hazlett,Susan Dowling-Zimmerman,Robert M. Post,John M. Morihisa,William T. Carpenter,Robert M. Cohen,David Pickar,Daniel R. Weinberger,Richard Margolin,R. M. Kessler +15 more
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TLDR
Local cerebral uptake of deoxyglucose labeled with fluorine 18 was measured by positron emission tomography in patients with schizophrenia and patients with affective disorder, sharing a lack of diagnostic specificity with many biologic measures.Citations
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Journal ArticleDOI
Comparison of prefrontal cell pathology between depression and alcohol dependence.
TL;DR: The present review compares the cell pathology in the prefrontal cortex between alcohol dependence and depression, and reveals both similarities and differences.
Journal ArticleDOI
Effects of metabolic perturbation on plasma homovanillic acid in schizophrenia. Relationship to prefrontal cortex volume.
TL;DR: The hypothesis that schizophrenia is associated with abnormal regulation of dopamine and that this deficit may be related to reduced frontal cortical inhibitory influences is supported.
Journal ArticleDOI
Cerebral laterality and emotion: The neurology of depression
TL;DR: A converging body of clinical and experimental studies indicate that the right hemisphere may be uniquely specialized for the perception, experience, and expression of emotion.
Journal ArticleDOI
Abnormal glucose metabolism in the anterior cingulate cortex in patients with schizophrenia
Toshiro Fujimoto,Kouzou Takeuch,Tetsuro Matsumoto,Kiyohisa Kamimura,Ryuichiro Hamada,Katsumi Nakamura,Nobumasa Kato +6 more
TL;DR: FDG-PET demonstrated that schizophrenia may be a disorder with a dysfunction of fronto-striatal-thalamic circuitry including the cingulate cortex, and changed glucose metabolism was studied in schizophrenic patients treated with neuroleptics, suggesting gender-related dysfunction in the anterior cingulates and thalamus in schizophrenia.
Journal ArticleDOI
Disturbed endocrine function in the psychoses. I: Disordered homeostasis or disease process?
Lawrence J. Whalley,J E Christie,Douglas Blackwood,J. Bennie,H. Dick,I. M. Blackburn,George Fink +6 more
TL;DR: The findings are not consistent with the view that the hormonal changes of the psychoses simply reflect a non-specific response to stress, or that the biological abnormalities of the Psychoses can be accounted for by a single continuum of disturbance.
References
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Manual for the State-Trait Anxiety Inventory
TL;DR: The STAI as mentioned in this paper is an indicator of two types of anxiety, the state and trait anxiety, and measure the severity of the overall anxiety level, which is appropriate for those who have at least a sixth grade reading level.
Journal ArticleDOI
The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.
Louis Sokoloff,Martin Reivich,Charles Kennedy,Charles Kennedy,M. H. Des Rosiers,Clifford S. Patlak,Karen D. Pettigrew,O. Sakurada,M. Shinohara +8 more
TL;DR: The method can be applied to most laboratory animals in the conscious state and is based on the use of 2‐deoxy‐D‐[14C]glucose as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues.
Journal ArticleDOI
A Diagnostic Interview: The Schedule for Affective Disorders and Schizophrenia
Jean Endicott,Robert L. Spitzer +1 more
TL;DR: Initial scale development and reliability studies of the items and the scale scores are reported on.
Journal ArticleDOI
Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method.
Michael E. Phelps,Michael E. Phelps,Sung-Cheng Huang,Sung-Cheng Huang,Edward J. Hoffman,Edward J. Hoffman,Carl Selin,Carl Selin,L. Sokoloff,L. Sokoloff,David E. Kuhl,David E. Kuhl +11 more
TL;DR: The data indicate that cerebral FDG‐6‐PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
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