Journal ArticleDOI
Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders.
Monte S. Buchsbaum,Lynn E. DeLisi,Henry H. Holcomb,J. Cappelletti,A C King,Jeannette L. Johnson,Erin A. Hazlett,Susan Dowling-Zimmerman,Robert M. Post,John M. Morihisa,William T. Carpenter,Robert M. Cohen,David Pickar,Daniel R. Weinberger,Richard Margolin,R. M. Kessler +15 more
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TLDR
Local cerebral uptake of deoxyglucose labeled with fluorine 18 was measured by positron emission tomography in patients with schizophrenia and patients with affective disorder, sharing a lack of diagnostic specificity with many biologic measures.Citations
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Journal ArticleDOI
Regional cerebral blood flow changes following chronic administration of antidepressant drugs.
TL;DR: Besides confirming frontal lobe dysfunction in depressed patients which is reversed by treatment with classic tricyclic antidepressants, the present results show that this dysfunction may also be reversed by Treatment with dopaminergic drugs.
Journal ArticleDOI
Rumination in bipolar disorder: evidence for an unquiet mind
TL;DR: The hypothesis is proposed that rumination in bipolar disorder, in both manic and depressed states, reflects executive dysfunction, and the neurobiology of rumination is related to the neuro biology of emotion regulation, which is disrupted in bipolar Disorder.
Journal ArticleDOI
Cerebral glucose metabolism in childhood onset schizophrenia
Leslie K. Jacobsen,Susan D. Hamburger,John D. Van Horn,A. Catherine Vaituzis,Kathleen McKenna,Jean A. Frazier,Charles T. Gordon,Marge Lenane,Judith L. Rapoport,Alan J. Zametkin +9 more
TL;DR: It is suggested that childhood onset schizophrenia may be associated with a similar, but not more severe, degree of hypofrontality relative to that seen in adult onset schizophrenia.
Journal ArticleDOI
Cortical “stress tests” in schizophrenia: Regional cerebral blood flow studies
TL;DR: It is suggested that schizophrenia is characterized by a deficit in prefrontal function that is revealed when regionally specific demand exceeds the physiological capacity, and that functional brain imaging studies, such as rCBF, can best identify brain abnormalities during "cortical stress tests."
Journal ArticleDOI
Neural correlates of cognitive impairment in schizophrenia
Jordi Ortiz-Gil,Edith Pomarol-Clotet,Raymond Salvador,Erick J. Canales-Rodríguez,Salvador Sarró,Jesus J. Gomar,A. Guerrero,Bibiana Sans-Sansa,Antoni Capdevila,Carme Junqué,Peter J. McKenna +10 more
TL;DR: Cognitive impairment in schizophrenia is not a function of the structural brain abnormality that accompanies the disorder but has correlates in altered brain function.
References
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Manual for the State-Trait Anxiety Inventory
TL;DR: The STAI as mentioned in this paper is an indicator of two types of anxiety, the state and trait anxiety, and measure the severity of the overall anxiety level, which is appropriate for those who have at least a sixth grade reading level.
Journal ArticleDOI
The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.
Louis Sokoloff,Martin Reivich,Charles Kennedy,Charles Kennedy,M. H. Des Rosiers,Clifford S. Patlak,Karen D. Pettigrew,O. Sakurada,M. Shinohara +8 more
TL;DR: The method can be applied to most laboratory animals in the conscious state and is based on the use of 2‐deoxy‐D‐[14C]glucose as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues.
Journal ArticleDOI
A Diagnostic Interview: The Schedule for Affective Disorders and Schizophrenia
Jean Endicott,Robert L. Spitzer +1 more
TL;DR: Initial scale development and reliability studies of the items and the scale scores are reported on.
Journal ArticleDOI
Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method.
Michael E. Phelps,Michael E. Phelps,Sung-Cheng Huang,Sung-Cheng Huang,Edward J. Hoffman,Edward J. Hoffman,Carl Selin,Carl Selin,L. Sokoloff,L. Sokoloff,David E. Kuhl,David E. Kuhl +11 more
TL;DR: The data indicate that cerebral FDG‐6‐PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
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Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence.
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David H. Ingvar,G. Franzén +1 more