Journal ArticleDOI
Anti-cancer drugs
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This article is published in Current Pharmaceutical Design.The article was published on 2005-03-31. It has received 882 citations till now. The article focuses on the topics: Introductory Journal Article.read more
Citations
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Synthesis and microbial assay of maltosyl tetrazino benzothiazoles
TL;DR: A new series of 3-oxo-4- hepta-O-benzoyl-β-D-maltosyl-(1,2,4,5)-tetrazino-(2,1b)-benzothiazoles is synthesized by the oxidative cyclisation of 1-hepta- O-benZoyl -β- D-mALTosyl-4 -benz Rothiazolyl semicarbazides to get potent bio
Synthesis of Phenylsubstituted 2H,5HPyrano(4,3b)pyran5ones and Related Heterocycles via a Domino Knoevenagel Condensation/ 6Electron Electrocyclization of 4Hydroxy6phenyl2Hpyran2one with Cyclic and Acyclic ,Unsaturated Aldehydes under Different Conditions
TL;DR: In this article, a range of new 7-phenyl-2H,5H-pyrano[4,3-b]pyran-5-ones and related tricyclic heterocycles was prepared in a single step by means of a domino Knoevenagel condensation/6p-electron electrocyclization under different reaction conditions, including thermal and microwave conditions.
Dissertation
Design, Synthesis and Evaluation of Spiro-Bicyclo(2.2.2)octane Derivatives as Paclitaxel Mimetics
TL;DR: The primary intention with the work presented in this thesis was to design and synthesize pac litaxel mimetics, based on a rigid skeleton decorated with the groups important for the paclitaxel activity, based for a spiro-bicyclo-2,6-diones skeleton as a suitable substitute for the rigid paclitAXel core.
Dissertation
Nanocápsulas policatiónicas: nuevos sistemas para la liberación intracelular de fármacos antitumorales
TL;DR: In this paper, el principal objetivo de this trabajo ha sido el desarrollo de nuevas nanocapsulas polimericas for vehiculizar farmacos antitumorales.
References
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Journal ArticleDOI
The status of platinum anticancer drugs in the clinic and in clinical trials.
TL;DR: The status of platinum anticancer drugs currently approved for use, those undergoing clinical trials and those discontinued during clinical trials are updated, and the results in the context of where the field will develop over the next decade are discussed.
Journal ArticleDOI
Natural products to drugs: natural product derived compounds in clinical trials
Mark S. Butler,Mark S. Butler +1 more
TL;DR: Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural products for which clinical trials have been halted or discontinued since 2005.
Journal ArticleDOI
Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)
John Ramage,A Ahmed,J Ardill,N.D.S. Bax,David J. Breen,Martyn Caplin,Pippa Corrie,J Davar,Albert Davies,Val Lewington,Tim Meyer,John Newell-Price,Graeme J. Poston,N. Reed,Andrea Rockall,William P. Steward,Rajesh V. Thakker,C. Toubanakis,Juan W. Valle,Caroline S. Verbeke,Ashley B. Grossman +20 more
TL;DR: These guidelines update previous guidance published in 2005 and have been revised by a group who are members of the UK and Ireland Neuroendocrine Tumour Society with endorsement from the clinical committees of the British Society of Gastroenterology and others.
Journal ArticleDOI
Cellular distribution and functions of P2 receptor subtypes in different systems.
TL;DR: This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body.
Journal ArticleDOI
Natural products: an evolving role in future drug discovery.
Bhuwan B. Mishra,Vinod K. Tiwari +1 more
TL;DR: The present review describes natural products, semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious, immunological, cardiovascular, neurological, inflammatory and related diseases and oncology.