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Anti-cancer drugs
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This article is published in Current Pharmaceutical Design.The article was published on 2005-03-31. It has received 882 citations till now. The article focuses on the topics: Introductory Journal Article.read more
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Ring-Opening Polymerization-Mediated Controlled Formulation of Polylactide−Drug Nanoparticles
Rong Tong,Jianjun Cheng +1 more
TL;DR: A unique method for formulating doxorubicin-polylactide (Doxo-PLA) conjugate nanoparticles, known as nanoconjugates (NCs), through Doxo/(BDI)ZnN(TMS)(2)-mediated LA polymerizations may have widespread utility for controlled conjugation of hydroxyl-containing agents to polyesters and formation of corresponding nanoparticles.
Journal ArticleDOI
Metastasis review: from bench to bedside.
TL;DR: This review will focus on the recent studies and collect a comprehensive encyclopedia in molecular basis of metastasis, and then it will discuss some new potential therapeutics which target the metastasis pathways.
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Phase I Study of GRN1005 in Recurrent Malignant Glioma
Jan Drappatz,Andrew Brenner,Eric T. Wong,April F. Eichler,David Schiff,Morris D. Groves,Tom Mikkelsen,Steve Rosenfeld,John Sarantopoulos,Christina A. Meyers,Robert M. Fielding,Kelly Elian,Xiaolin Wang,Betty Lawrence,Mona Shing,Stephen M. Kelsey,Jean Paul Castaigne,Patrick Y. Wen +17 more
TL;DR: GRN1005 delivers paclitaxel across the BBB and achieves therapeutic concentrations in tumor tissue and appears to have activity in recurrent glioma.
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Architecturally Induced Multiresponsive Vesicles from Well-Defined Polypeptides. Formation of Gene Vehicles
Hermis Iatrou,Henrich Frielinghaus,Sirkku Hanski,Nikos Ferderigos,Janne Ruokolainen,Olli Ikkala,Dieter Prof. Dr. Richter,Jimmy W. Mays,Nikos Hadjichristidis +8 more
TL;DR: The synthesized vectors combine the advantages of the polylysine- DNA systems to condense large amounts of genes, as well as those of the liposome-DNA systems to better protect the encapsulated DNA.
References
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Journal ArticleDOI
The status of platinum anticancer drugs in the clinic and in clinical trials.
TL;DR: The status of platinum anticancer drugs currently approved for use, those undergoing clinical trials and those discontinued during clinical trials are updated, and the results in the context of where the field will develop over the next decade are discussed.
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Natural products to drugs: natural product derived compounds in clinical trials
Mark S. Butler,Mark S. Butler +1 more
TL;DR: Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural products for which clinical trials have been halted or discontinued since 2005.
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Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)
John Ramage,A Ahmed,J Ardill,N.D.S. Bax,David J. Breen,Martyn Caplin,Pippa Corrie,J Davar,Albert Davies,Val Lewington,Tim Meyer,John Newell-Price,Graeme J. Poston,N. Reed,Andrea Rockall,William P. Steward,Rajesh V. Thakker,C. Toubanakis,Juan W. Valle,Caroline S. Verbeke,Ashley B. Grossman +20 more
TL;DR: These guidelines update previous guidance published in 2005 and have been revised by a group who are members of the UK and Ireland Neuroendocrine Tumour Society with endorsement from the clinical committees of the British Society of Gastroenterology and others.
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Cellular distribution and functions of P2 receptor subtypes in different systems.
TL;DR: This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body.
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Natural products: an evolving role in future drug discovery.
Bhuwan B. Mishra,Vinod K. Tiwari +1 more
TL;DR: The present review describes natural products, semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious, immunological, cardiovascular, neurological, inflammatory and related diseases and oncology.